User profiles for SEAN JUDGE
Sean J. JudgeMemorial Sloan Kettering Cancer Center Verified email at mskcc.org Cited by 509 |
[HTML][HTML] Analysis of tumor-infiltrating NK and T cells highlights IL-15 stimulation and TIGIT blockade as a combination immunotherapy strategy for soft tissue sarcomas
… Sean J Judge, 1 Morgan A Darrow, 2 Steve W Thorpe, 3 Alicia A Gingrich, 1 Edmond F O'Donnell,
3 Alyssa R Bellini, 1 Ian R Sturgill, 4 Logan V Vick, 4 Cordelia Dunai, 4 Kevin M Stoffel, 4 …
3 Alyssa R Bellini, 1 Ian R Sturgill, 4 Logan V Vick, 4 Cordelia Dunai, 4 Kevin M Stoffel, 4 …
[HTML][HTML] Characterizing the dysfunctional NK cell: assessing the clinical relevance of exhaustion, anergy, and senescence
There is a growing body of literature demonstrating the importance of T cell exhaustion in
regulating and shaping immune responses to pathogens and cancer. Simultaneously, the …
regulating and shaping immune responses to pathogens and cancer. Simultaneously, the …
[HTML][HTML] Minimal PD-1 expression in mouse and human NK cells under diverse conditions
PD-1 expression is a hallmark of both early antigen-specific T cell activation and later chronic
stimulation, suggesting key roles in both naive T cell priming and memory T cell responses…
stimulation, suggesting key roles in both naive T cell priming and memory T cell responses…
[HTML][HTML] Inhaled recombinant human IL-15 in dogs with naturally occurring pulmonary metastases from osteosarcoma or melanoma: a phase 1 study of clinical activity …
Original research: Inhaled recombinant human IL-15 in dogs with naturally occurring
pulmonary metastases from osteosarcoma or melanoma: a phase 1 study of clinical activity and …
pulmonary metastases from osteosarcoma or melanoma: a phase 1 study of clinical activity and …
[HTML][HTML] Intratumoral NKp46+ natural killer cells are spatially distanced from T and MHC-I+ cells with prognostic implications in soft tissue sarcoma
Introduction Soft tissue sarcomas (STS) are rare, heterogenous malignancies with an unmet
need for novel immunotherapies. Tumor infiltrating lymphocytes (TILs) have been linked …
need for novel immunotherapies. Tumor infiltrating lymphocytes (TILs) have been linked …
[HTML][HTML] Comparative immunogenomics of canine natural killer cells as immunotherapy target
Natural killer (NK) cells are key effectors of the innate immune system, but major differences
between human and murine NK cells have impeded translation. Outbred dogs offer an …
between human and murine NK cells have impeded translation. Outbred dogs offer an …
[HTML][HTML] Bortezomib augments natural killer cell targeting of stem-like tumor cells
Tumor cells harboring stem-like/cancer stem cell (CSC) properties have been identified and
isolated from numerous hematological and solid malignancies. These stem-like tumor cells …
isolated from numerous hematological and solid malignancies. These stem-like tumor cells …
Morbidity, mortality and temporal trends in the surgical management of retroperitoneal sarcoma: an ACS‐NSQIP follow up analysis
SJ Judge, K Lata‐Arias, M Yanagisawa… - Journal of Surgical …, 2019 - Wiley Online Library
Background Calls for multivisceral resection (MVR) of retroperitoneal sarcoma (RPS) are
increasing, although the risks and benefits remain controversial. We sought to analyze current …
increasing, although the risks and benefits remain controversial. We sought to analyze current …
[HTML][HTML] Transcriptome analysis of tumor-infiltrating lymphocytes identifies NK cell gene signatures associated with lymphocyte infiltration and survival in soft tissue …
SJ Judge, JD Bloomstein, CJ Sholevar… - Frontiers in …, 2022 - frontiersin.org
Purpose Clinical successes using current T-cell based immunotherapies have been limited
in soft tissue sarcomas (STS), while pre-clinical studies have shown evidence of natural killer …
in soft tissue sarcomas (STS), while pre-clinical studies have shown evidence of natural killer …
Is minimally invasive surgery of lesions in the right superior segments of the liver justified? A multi‐institutional study of 245 patients
Background Controversy exists regarding the safety and feasibility of minimally invasive
resection for lesions in segments 7 or 8. We compare outcomes of minimally invasive surgery (…
resection for lesions in segments 7 or 8. We compare outcomes of minimally invasive surgery (…