User profiles for SEAN JUDGE

Sean J. Judge

Memorial Sloan Kettering Cancer Center
Verified email at mskcc.org
Cited by 509

[HTML][HTML] Analysis of tumor-infiltrating NK and T cells highlights IL-15 stimulation and TIGIT blockade as a combination immunotherapy strategy for soft tissue sarcomas

SJ Judge, MA Darrow, SW Thorpe… - … for immunotherapy of …, 2020 - ncbi.nlm.nih.gov
Sean J Judge, 1 Morgan A Darrow, 2 Steve W Thorpe, 3 Alicia A Gingrich, 1 Edmond F O'Donnell,
3 Alyssa R Bellini, 1 Ian R Sturgill, 4 Logan V Vick, 4 Cordelia Dunai, 4 Kevin M Stoffel, 4 …

[HTML][HTML] Characterizing the dysfunctional NK cell: assessing the clinical relevance of exhaustion, anergy, and senescence

SJ Judge, WJ Murphy, RJ Canter - Frontiers in cellular and infection …, 2020 - frontiersin.org
There is a growing body of literature demonstrating the importance of T cell exhaustion in
regulating and shaping immune responses to pathogens and cancer. Simultaneously, the …

[HTML][HTML] Minimal PD-1 expression in mouse and human NK cells under diverse conditions

SJ Judge, C Dunai, EG Aguilar, SC Vick… - The Journal of …, 2020 - Am Soc Clin Investig
PD-1 expression is a hallmark of both early antigen-specific T cell activation and later chronic
stimulation, suggesting key roles in both naive T cell priming and memory T cell responses…

[HTML][HTML] Inhaled recombinant human IL-15 in dogs with naturally occurring pulmonary metastases from osteosarcoma or melanoma: a phase 1 study of clinical activity …

RB Rebhun, D York, SM Cruz, SJ Judge… - … for immunotherapy of …, 2022 - ncbi.nlm.nih.gov
Original research: Inhaled recombinant human IL-15 in dogs with naturally occurring
pulmonary metastases from osteosarcoma or melanoma: a phase 1 study of clinical activity and …

[HTML][HTML] Intratumoral NKp46+ natural killer cells are spatially distanced from T and MHC-I+ cells with prognostic implications in soft tissue sarcoma

SM Cruz, CJ Sholevar, SJ Judge, M Lammers… - Frontiers in …, 2023 - frontiersin.org
Introduction Soft tissue sarcomas (STS) are rare, heterogenous malignancies with an unmet
need for novel immunotherapies. Tumor infiltrating lymphocytes (TILs) have been linked …

[HTML][HTML] Comparative immunogenomics of canine natural killer cells as immunotherapy target

AA Gingrich, TE Reiter, SJ Judge, D York… - Frontiers in …, 2021 - frontiersin.org
Natural killer (NK) cells are key effectors of the innate immune system, but major differences
between human and murine NK cells have impeded translation. Outbred dogs offer an …

[HTML][HTML] Bortezomib augments natural killer cell targeting of stem-like tumor cells

…, SK Grossenbacher, IR Sturgill, E Ames, SJ Judge… - Cancers, 2019 - mdpi.com
Tumor cells harboring stem-like/cancer stem cell (CSC) properties have been identified and
isolated from numerous hematological and solid malignancies. These stem-like tumor cells …

Morbidity, mortality and temporal trends in the surgical management of retroperitoneal sarcoma: an ACS‐NSQIP follow up analysis

SJ Judge, K Lata‐Arias, M Yanagisawa… - Journal of Surgical …, 2019 - Wiley Online Library
Background Calls for multivisceral resection (MVR) of retroperitoneal sarcoma (RPS) are
increasing, although the risks and benefits remain controversial. We sought to analyze current …

[HTML][HTML] Transcriptome analysis of tumor-infiltrating lymphocytes identifies NK cell gene signatures associated with lymphocyte infiltration and survival in soft tissue …

SJ Judge, JD Bloomstein, CJ Sholevar… - Frontiers in …, 2022 - frontiersin.org
Purpose Clinical successes using current T-cell based immunotherapies have been limited
in soft tissue sarcomas (STS), while pre-clinical studies have shown evidence of natural killer …

Is minimally invasive surgery of lesions in the right superior segments of the liver justified? A multi‐institutional study of 245 patients

S Gholami, SJ Judge, SY Lee… - Journal of surgical …, 2020 - Wiley Online Library
Background Controversy exists regarding the safety and feasibility of minimally invasive
resection for lesions in segments 7 or 8. We compare outcomes of minimally invasive surgery (…