User profiles for SAUL ROSENBERG

Saul H. Rosenberg

Abbvie
Verified email at abbvie.com
Cited by 27558

An inhibitor of Bcl-2 family proteins induces regression of solid tumours

…, MD Wendt, H Zhang, SW Fesik, SH Rosenberg - Nature, 2005 - nature.com
Proteins in the Bcl-2 family are central regulators of programmed cell death 1 , and members
that inhibit apoptosis, such as Bcl-X L and Bcl-2, are overexpressed in many cancers and …

Inventory of interpersonal problems: psychometric properties and clinical applications.

LM Horowitz, SE Rosenberg, BA Baer… - Journal of consulting …, 1988 - psycnet.apa.org
This article describes a new instrument, the Inventory of Interpersonal Problems (IIP), which
measures distress arising from interpersonal sources. The IIP meets the need for an easily …

ABT-199, a potent and selective BCL-2 inhibitor, achieves antitumor activity while sparing platelets

…, H Zhang, RA Humerickhouse, SH Rosenberg… - Nature medicine, 2013 - nature.com
Proteins in the B cell CLL/lymphoma 2 (BCL-2) family are key regulators of the apoptotic
process. This family comprises proapoptotic and prosurvival proteins, and shifting the balance …

ABT-263: a potent and orally bioavailable Bcl-2 family inhibitor

…, Y Xiao, X Yang, H Zhang, S Fesik, SH Rosenberg… - Cancer research, 2008 - AACR
Overexpression of the prosurvival Bcl-2 family members (Bcl-2, Bcl-xL, and Mcl-1) is commonly
associated with tumor maintenance, progression, and chemoresistance. We previously …

The natural history of initially untreated low-grade non-Hodgkin's lymphomas

SJ Horning, SA Rosenberg - New England Journal of Medicine, 1984 - Mass Medical Soc
To learn more about the natural history of low-grade non-Hodgkin's lymphoma, we have
studied 83 patients in whom the advanced disease was initially managed without therapy. …

Lymphosarcoma: a review of 1269 cases

SA Rosenberg, HD Diamond, B Jaslowitz, LF Craver - Medicine, 1961 - journals.lww.com
ROSENBERG, SAUL A.; DIAMOND, HENRY D.; JASLOWITZ, BERNARD; CRAVER,
LLOYD F. … Other articles in this journal by SAUL A. ROSENBERG

Interpersonal problems, attachment styles, and outcome in brief dynamic psychotherapy.

LM Horowitz, SE Rosenberg… - Journal of consulting …, 1993 - psycnet.apa.org
The Inventory of Interpersonal Problems (IIP) has been used to identify dysfunctional patterns
in interpersonal interactions. Interpersonal problems can be organized in 2 dimensions, …

ABT-888, an orally active poly (ADP-ribose) polymerase inhibitor that potentiates DNA-damaging agents in preclinical tumor models

…, AC Tsurutani, GD Zhu, SH Rosenberg… - Clinical cancer …, 2007 - AACR
Purpose: To evaluate the preclinical pharmacokinetics and antitumor efficacy of a novel
orally bioavailable poly(ADP-ribose) polymerase (PARP) inhibitor, ABT-888. Experimental …

Navitoclax, a targeted high-affinity inhibitor of BCL-2, in lymphoid malignancies: a phase 1 dose-escalation study of safety, pharmacokinetics, pharmacodynamics, and …

…, Y Cui, T Busman, SW Elmore, SH Rosenberg… - The lancet …, 2010 - thelancet.com
Background Proteins of the BCL-2 family regulate clonal selection and survival of
lymphocytes, and are frequently overexpressed in lymphomas. Navitoclax is a targeted high-affinity …

The promise and peril of chemical probes

…, JP Overington, DR Owen, SH Rosenberg… - Nature chemical …, 2015 - nature.com
Chemical probes are powerful reagents with increasing impacts on biomedical research.
However, probes of poor quality or that are used incorrectly generate misleading results. To …