Adjustment of the lysosomal-mitochondrial axis for control of cellular senescence

JT Park, YS Lee, KA Cho, SC Park - Ageing research reviews, 2018 - Elsevier
Mitochondria and lysosomes undergo the most marked senescence-related alterations
among all cellular organelles. Whereas mitochondria undergo gradual structural changes …

[HTML][HTML] Targeting mitochondrial metabolism as a strategy to treat senescence

…, MU Kuk, J Joo, S Oh, HW Kwon, JT Park, SC Park - Cells, 2021 - mdpi.com
Mitochondria are one of organelles that undergo significant changes associated with senescence.
An increase in mitochondrial size is observed in senescent cells, and this increase is …

[HTML][HTML] Autophagy impairment induces premature senescence in primary human fibroblasts

HT Kang, KB Lee, SY Kim, HR Choi, SC Park - PloS one, 2011 - journals.plos.org
Background Recent studies have demonstrated that activation of autophagy increases the
lifespan of organisms from yeast to flies. In contrast to the lifespan extension effect in lower …

Targeting major vault protein in senescence-associated apoptosis resistance

SJ Ryu, SC Park - Expert opinion on therapeutic targets, 2009 - Taylor & Francis
Background: Recent studies have shown that major vault protein (MVP) is involved in
intracellular signaling, cell survival, differentiation and innate immunity and that it is not directly …

[HTML][HTML] Morphological adjustment of senescent cells by modulating caveolin-1 status

KA Cho, SJ Ryu, YS Oh, JH Park, JW Lee… - Journal of Biological …, 2004 - ASBMB
Morphological change is one of the cardinal features of the senescent phenotype; for
example, senescent human diploid cells have a flat large shape. However, the mechanisms …

[HTML][HTML] Up-regulation of caveolin attenuates epidermal growth factor signaling in senescent cells

WY Park, JS Park, KA Cho, DI Kim, YG Ko… - Journal of Biological …, 2000 - ASBMB
Senescent human diploid fibroblasts do not respond to growth factors like epidermal growth
factor (EGF), although they have a normal level of receptors and downstream signaling …

The Fourth Industrial Revolution and implications for innovative cluster policies

SC Park - Ai & Society, 2018 - Springer
The Fourth Industrial Revolution has become a global buzz word since the World Economic
Forum (WEF) adopted it as an annual issue in 2016. It is represented by hyper automation …

Chemical screening identifies ATM as a target for alleviating senescence

HT Kang, JT Park, K Choi, Y Kim, HJC Choi… - Nature chemical …, 2017 - nature.com
Senescence, defined as irreversible cell-cycle arrest, is the main driving force of aging and
age-related diseases. Here, we performed high-throughput screening to identify compounds …

Higher antioxidant properties of Chungkookjang, a fermented soybean paste, may be due to increased aglycone and malonylglycoside isoflavone during fermentation

CS Kwak, MS Lee, SC Park - Nutrition Research, 2007 - Elsevier
Chungkookjang (CKJ), a popular fermented soybean paste in Korea, has been considered
to be more healthful than soybeans. To verify this, we compared in vitro and in vivo …

Increased caveolin-1, a cause for the declined adipogenic potential of senescent human mesenchymal stem cells

JS Park, HY Kim, HW Kim, GN Chae, HT Oh… - Mechanisms of ageing …, 2005 - Elsevier
Mesenchymal stem cell (MSC) has drawn much attention in the aspect of tissue renewal
and wound healing because of its multipotency. We initially observed that bone marrow-derived …