Adjustment of the lysosomal-mitochondrial axis for control of cellular senescence
JT Park, YS Lee, KA Cho, SC Park - Ageing research reviews, 2018 - Elsevier
Mitochondria and lysosomes undergo the most marked senescence-related alterations
among all cellular organelles. Whereas mitochondria undergo gradual structural changes …
among all cellular organelles. Whereas mitochondria undergo gradual structural changes …
[HTML][HTML] Targeting mitochondrial metabolism as a strategy to treat senescence
Mitochondria are one of organelles that undergo significant changes associated with senescence.
An increase in mitochondrial size is observed in senescent cells, and this increase is …
An increase in mitochondrial size is observed in senescent cells, and this increase is …
[HTML][HTML] Autophagy impairment induces premature senescence in primary human fibroblasts
Background Recent studies have demonstrated that activation of autophagy increases the
lifespan of organisms from yeast to flies. In contrast to the lifespan extension effect in lower …
lifespan of organisms from yeast to flies. In contrast to the lifespan extension effect in lower …
Targeting major vault protein in senescence-associated apoptosis resistance
SJ Ryu, SC Park - Expert opinion on therapeutic targets, 2009 - Taylor & Francis
Background: Recent studies have shown that major vault protein (MVP) is involved in
intracellular signaling, cell survival, differentiation and innate immunity and that it is not directly …
intracellular signaling, cell survival, differentiation and innate immunity and that it is not directly …
[HTML][HTML] Morphological adjustment of senescent cells by modulating caveolin-1 status
KA Cho, SJ Ryu, YS Oh, JH Park, JW Lee… - Journal of Biological …, 2004 - ASBMB
Morphological change is one of the cardinal features of the senescent phenotype; for
example, senescent human diploid cells have a flat large shape. However, the mechanisms …
example, senescent human diploid cells have a flat large shape. However, the mechanisms …
[HTML][HTML] Up-regulation of caveolin attenuates epidermal growth factor signaling in senescent cells
Senescent human diploid fibroblasts do not respond to growth factors like epidermal growth
factor (EGF), although they have a normal level of receptors and downstream signaling …
factor (EGF), although they have a normal level of receptors and downstream signaling …
The Fourth Industrial Revolution and implications for innovative cluster policies
SC Park - Ai & Society, 2018 - Springer
The Fourth Industrial Revolution has become a global buzz word since the World Economic
Forum (WEF) adopted it as an annual issue in 2016. It is represented by hyper automation …
Forum (WEF) adopted it as an annual issue in 2016. It is represented by hyper automation …
Chemical screening identifies ATM as a target for alleviating senescence
HT Kang, JT Park, K Choi, Y Kim, HJC Choi… - Nature chemical …, 2017 - nature.com
Senescence, defined as irreversible cell-cycle arrest, is the main driving force of aging and
age-related diseases. Here, we performed high-throughput screening to identify compounds …
age-related diseases. Here, we performed high-throughput screening to identify compounds …
Higher antioxidant properties of Chungkookjang, a fermented soybean paste, may be due to increased aglycone and malonylglycoside isoflavone during fermentation
CS Kwak, MS Lee, SC Park - Nutrition Research, 2007 - Elsevier
Chungkookjang (CKJ), a popular fermented soybean paste in Korea, has been considered
to be more healthful than soybeans. To verify this, we compared in vitro and in vivo …
to be more healthful than soybeans. To verify this, we compared in vitro and in vivo …
Increased caveolin-1, a cause for the declined adipogenic potential of senescent human mesenchymal stem cells
JS Park, HY Kim, HW Kim, GN Chae, HT Oh… - Mechanisms of ageing …, 2005 - Elsevier
Mesenchymal stem cell (MSC) has drawn much attention in the aspect of tissue renewal
and wound healing because of its multipotency. We initially observed that bone marrow-derived …
and wound healing because of its multipotency. We initially observed that bone marrow-derived …