Effectiveness of a vaccine against red sea bream iridoviral disease in a field trial test

…, K Yokoyama, T Tooriyama, S Manabe - Diseases of Aquatic …, 1999 - int-res.com
Since 1990, red sea bream iridovirus (RSIV) has caused high mortalities in the summertime
in cultured red sea bream Pagrus major in southwest Japan. To establish control measures …

Production of nonstructural proteins of hepatitis C virus requires a putative viral protease encoded by NS3

S Manabe, I Fuke, O Tanishita, C Kaji, Y Gomi… - Virology, 1994 - Elsevier
Hepatitis C virus (HCV) is a positive strand RNA virus with certain similarity to flaviviruses
and pestiviruses. To examine the processing and possible assembly of HCV proteins, we …

Application of the arming system for the expression of the 380R antigen from red sea bream iridovirus (RSIV) on the surface of yeast cells: a first step for the …

Y Tamaru, M Ohtsuka, K Kato, S Manabe… - Biotechnology …, 2006 - Wiley Online Library
The cell surface is a functional interface between the inside and the outside of the cell.
Moreover, cells have systems for anchoring surface specific proteins and for confining surface …

Antigen analysis of red sea bream iridovirus and comparison with other fish iridoviruses

…, Y Maeno, K Yokoyama, C Kaji, S Manabe - Fish …, 1998 - jstage.jst.go.jp
Results Cross indirect immunofluorescence assays with the RSIV isolates from cultured
marine fishes in Japan The reactivities among RSIV isolates from cultured marine fishes using …

Effectiveness of a vaccine against red sea bream iridoviral disease in various cultured marine fish under laboratory conditions

…, T Itano, Y Fukuda, Y Aoi, T Tooriyama, S Manabe - Fish …, 2002 - jstage.jst.go.jp
The effectiveness of a vaccine made of the cell culture supernatant of RSIV (red sea bream
iridovirus) infected cells inactivated with formalin (0.1% v/v) in yellow tail Seriola …

Anti-tumor effect of intravenous administration of CRM197 for triple-negative breast cancer therapy

…, S Fukagawa, T Odawara, S Manabe… - Anticancer …, 2016 - ar.iiarjournals.org
Background/Aim: Heparin-binding epidermal growth factor-like growth factor (HB-EGF),
which belongs to the epidermal growth factor family, is a rational therapeutic target for triple-…

HB-EGF is a promising therapeutic target for lung cancer with secondary mutation of EGFRT790M

…, D Miyahara, T Odawara, S Manabe… - Anticancer …, 2017 - ar.iiarjournals.org
Advanced lung cancer is one of the most lethal malignancies. Many anticancer agents have
been developed for lung cancer with epidermal growth factor receptor (EGFR) mutations, …

Antitumor effects of CRM197, a specific inhibitor of HB-EGF, in T-cell acute lymphoblastic leukemia

…, K Ishitsuka, T Fukami, T Odawara, S Manabe… - Anticancer …, 2011 - ar.iiarjournals.org
The therapeutic outcome for T-cell acute lymphoblastic leukemia (T-ALL) remains poor; thus,
novel, targeted therapies are urgently needed. Recently, we showed that heparin-binding …

Characterization of neutralizing antibodies in adults after intranasal vaccination with an inactivated influenza vaccine

…, T Tanimoto, Y Gomi, S Manabe… - Journal of medical …, 2012 - Wiley Online Library
The levels and properties of neutralizing antibodies in nasal wash and serum collected from
five healthy adults were examined after intranasal administration of an A/Uruguay/716/2007 …

[HTML][HTML] BK-UM in patients with recurrent ovarian cancer or peritoneal cancer: a first-in-human phase-I study

…, S Nishino, T Odawara, K Maeda, S Manabe… - BMC cancer, 2017 - Springer
Background BK-UM (CRM197) is a mutant form of diphtheria toxin and a specific inhibitor of
heparin-binding epidermal growth factor-like growth factor (HB-EGF). We assessed the …