Consensus guidelines for the detection of immunogenic cell death

…, M Herrmann, JW Hodge, S Holdenrieder… - …, 2014 - Taylor & Francis
Apoptotic cells have long been considered as intrinsically tolerogenic or unable to elicit
immune responses specific for dead cell-associated antigens. However, multiple stimuli can …

[HTML][HTML] The emerging role of cell-free DNA as a molecular marker for cancer management

AJ Bronkhorst, V Ungerer, S Holdenrieder - Biomolecular detection and …, 2019 - Elsevier
An increasing number of studies demonstrate the potential use of cell-free DNA (cfDNA) as
a surrogate marker for multiple indications in cancer, including diagnosis, prognosis, and …

[HTML][HTML] Putative origins of cell-free DNA in humans: a review of active and passive nucleic acid release mechanisms

S Grabuschnig, AJ Bronkhorst, S Holdenrieder… - International journal of …, 2020 - mdpi.com
Through various pathways of cell death, degradation, and regulated extrusion, partial or
complete genomes of various origins (eg, host cells, fetal cells, and infiltrating viruses and …

Reciprocal coupling of coagulation and innate immunity via neutrophil serine proteases

…, E Kennerknecht, K Reges, S Holdenrieder, S Braun… - Nature medicine, 2010 - nature.com
s compared to the coagulation time of 699 ± 46 s for isotype control IgG (mean values ±
sem, n = 7, P < 0.05; in line with the results in ref. 29). Coagulation in this system also involved …

Investigation of miR-21, miR-141, and miR-221 in blood circulation of patients with prostate cancer

…, Y Dizdar, E Darendeliler, S Holdenrieder… - Tumor Biology, 2011 - Springer
… start step of 10 min at 95C followed by 45 cycles of amplification where each cycle consisted
of denaturation at 95C for 10 s, annealing at 60C for 10 s, and elongation at 70C for 10 s. …

Soluble MICA in malignant diseases

S Holdenrieder, P Stieber, A Peterfi… - … journal of cancer, 2006 - Wiley Online Library
The immunoreceptor NKG2D activates natural killer cells and costimulates CD8 T cells. The
MHC class I–related MICA molecules are ligands of NKG2D and are expressed on …

[HTML][HTML] MicroRNAs in renal cell carcinoma: diagnostic implications of serum miR-1233 levels

LM Wulfken, R Moritz, C Ohlmann, S Holdenrieder… - PloS one, 2011 - journals.plos.org
Background MicroRNA expression is altered in cancer cells, and microRNAs could serve as
diagnostic/prognostic biomarker for cancer patients. Our study was designed to analyze …

[HTML][HTML] Clinical validation of an autoantibody test for lung cancer

P Boyle, CJ Chapman, S Holdenrieder, A Murray… - Annals of …, 2011 - Elsevier
Background Autoantibodies may be present in a variety of underlying cancers several years
before tumours can be detected and testing for their presence may allow earlier diagnosis. …

Clinical use of circulating nucleosomes

S Holdenrieder, P Stieber - Critical reviews in clinical laboratory …, 2009 - Taylor & Francis
Nucleosomes, complexes of DNA and histone proteins, are released from dying and stressed
cells into the blood circulation. Concentrations of circulating nucleosomes in plasma and …

Prognostic and therapeutic significance of carbohydrate antigen 19-9 as tumor marker in patients with pancreatic cancer

S Boeck, P Stieber, S Holdenrieder, R Wilkowski… - Oncology, 2006 - karger.com
In pancreatic cancer (PC) accurate determination of treatment response by imaging often
remains difficult. Various efforts have been undertaken to investigate new factors which may …