MicroRNA-21 regulates the proliferation and invasion in esophageal squamous cell carcinoma

Y Hiyoshi, H Kamohara, R Karashima, N Sato… - Clinical cancer …, 2009 - AACR
Purpose: MicroRNAs are ∼22 nucleotide noncoding RNA molecules that posttranscriptionally
regulate gene expression. The aim of this study was (a) to determine a role of microRNA-…

Sarcopenia is a predictor of postoperative respiratory complications in patients with esophageal cancer

…, Y Baba, N Umezaki, K Harada, R Karashima… - Annals of surgical …, 2015 - Springer
Background Depletion of skeletal muscle mass (sarcopenia) indicates a poor prognosis for
patients with several kinds of cancer, but it remains unclear whether esophageal squamous …

Preoperative controlling nutritional status (CONUT) is useful to estimate the prognosis after esophagectomy for esophageal cancer

…, Y Sakamoto, Y Miyamoto, R Karashima… - … archives of surgery, 2017 - Springer
Purpose The aim of this study is to confirm the predictive value of controlling nutritional
status (CONUT), as a postoperative prognostic marker for esophageal cancer patients …

Induction chemotherapy with docetaxel/cisplatin/5-fluorouracil for patients with node-positive esophageal cancer

…, K Kinoshita, S Saito, J Kurashige, R Karashima… - Digestion, 1955 - karger.com
Background: Despite improvements in the surgical management of esophageal cancer, the
prognosis of patients with lymph node metastases is still unsatisfactory. Recently, survival …

Changes in body composition secondary to neoadjuvant chemotherapy for advanced esophageal cancer are related to the occurrence of postoperative complications …

S Ida, M Watanabe, R Karashima, Y Imamura… - Annals of surgical …, 2014 - Springer
Background Although a survival benefit of neoadjuvant treatment for patients with esophageal
cancer has been highlighted, the influence of neoadjuvant treatment on the nutritional …

Clinical significance of Wnt-induced secreted protein-1 (WISP-1/CCN4) in esophageal squamous cell carcinoma

…, M Watanabe, S Ishikawa, R Karashima… - Anticancer …, 2011 - ar.iiarjournals.org
Background/Aim: The expression of Wingless/int-1 (Wnt)-induced secreted protein-1 (WISP-1/CCN4),
a member of the Cyr61-CTGF-Nov (CCN) family, has been examined in several …

Lymphatic vessel invasion detected by the D2‐40 monoclonal antibody is an independent prognostic factor in node‐negative esophageal squamous cell carcinoma

…, Y Baba, K Hirashima, R Karashima… - Journal of surgical …, 2012 - Wiley Online Library
Background and Objectives D2‐40 staining has been reported to be useful for both identifying
lymphatic vessel invasion (LVI) and counting lymphatic vessel density (LVD) in various …

Advantages of FDG-PET/CT over CT alone in the preoperative assessment of lymph node metastasis in patients with esophageal cancer

R Karashima, M Watanabe, Y Imamura, S Ida, Y Baba… - Surgery today, 2015 - Springer
Purpose The aim of this study was to determine the benefits of 18 F-fluorodeoxyglucose
positron emission tomography (PET)/computed tomography (CT) compared to CT alone in the …

p53 immunohistochemical expression and patient prognosis in esophageal squamous cell carcinoma

…, M Watanabe, H Shigaki, K Miyake, R Karashima… - Medical Oncology, 2013 - Springer
It is generally accepted that overexpression of p53 protein is associated with poor prognosis
in gastric, lung, and other types of cancer. However, the prognostic significance of p53 …

Surgery for Hepatocellular Carcinoma With Macroscopic Vascular Invasion in the Era of Modern Molecular Therapy

…, K Imai, H Hayashi, E Oda, R Karashima… - Anticancer …, 2023 - ar.iiarjournals.org
It has been reported that patients with macroscopic vascular invasion accompanying
hepatocellular carcinoma have a poor prognosis. Modern molecular therapy with multitargeted …