[HTML][HTML] Rapidly generated multivirus-specific cytotoxic T lymphocytes for the prophylaxis and treatment of viral infections

U Gerdemann, JM Keirnan, UL Katari, R Yanagisawa… - Molecular therapy, 2012 - cell.com
Severe and fatal viral infections remain common after hematopoietic stem cell transplantation.
Adoptive transfer of cytotoxic T lymphocytes (CTLs) specific for Epstein–Barr virus (EBV), …

[HTML][HTML] Reversal of tumor immune inhibition using a chimeric cytokine receptor

…, S Mohammed, J Keirnan, R Yanagisawa… - Molecular Therapy, 2014 - cell.com
The success of adoptively transferred tumor-directed T cells requires them to survive and
expand in vivo. Most tumors, however, employ immune evasion mechanisms, including the …

Spontaneous improvement of hematologic abnormalities in patients having juvenile myelomonocytic leukemia with specific RAS mutations

…, K Yamauchi, M Tanaka, R Yanagisawa… - Blood, The Journal …, 2007 - ashpublications.org
Of 11 children with juvenile myelomonocytic leukemia (JMML) carrying RAS mutations (8
with NRAS mutations, 3 with KRAS2 mutations), 5 had a profound elevation in either or both …

Clinical Significance of Cloned Expansion and CD5 Down-Regulation in Epstein-Barr Virus (EBV)- Infected CD8 + T Lymphocytes in EBV-Associated …

…, T Toma, T Kurokawa, R Yanagisawa… - The Journal of …, 2010 - academic.oup.com
Epstein-Barr virus (EBV) is the pathogen that most commonly triggers infection-associated
hemophagocytic lymphohistiocytosis (HLH) and ectopically infects CD8 + T cells in EBV-…

WT1-pulsed dendritic cell vaccine combined with chemotherapy for resected pancreatic cancer in a phase I study

R Yanagisawa, T Koizumi, T Koya, K Sano… - Anticancer …, 2018 - ar.iiarjournals.org
Background/Aim: Wilms' tumor 1 (WT1) is a tumor-associated antigen highly expressed in
cancer. We examined the safety of WT1-peptide pulsed dendritic cell (WT1-DC) vaccine in …

The role of evaluation in achieving the SDGs

…, O Saito, K Hayashi, M Nagao, R Yanagisawa… - Sustainability …, 2017 - Springer
This paper proposes a framework on Sustainable Development Goal (SDG) evaluation, arguing
that attainment of the 17 goals and 169 related targets depends significantly on practice-…

Anti-leukemic potency of piggyBac-mediated CD19-specific T cells against refractory Philadelphia chromosome–positive acute lymphoblastic leukemia

…, A Sueki, K Matsuda, M Tanaka, R Yanagisawa… - Cytotherapy, 2014 - Elsevier
Background aims To develop a treatment option for Philadelphia chromosome–positive
acute lymphoblastic leukemia (Ph + ALL) resistant to tyrosine kinase inhibitors (TKIs), we …

Usefulness of allogeneic hematopoietic stem cell transplantation in first complete remission for pediatric blastic plasmacytoid dendritic cell neoplasm with skin …

K Sakashita, S Saito, R Yanagisawa… - Pediatric Blood & …, 2013 - Wiley Online Library
No standard treatment has been established in childhood blastic plasmacytoid dendritic cell
neoplasma (BPDCN) because of its rarity. We treated with acute lymphoblastic leukemia‐…

Safety and tolerability of allogeneic dendritic cell vaccination with induction of Wilms tumor 1–specific T cells in a pediatric donor and pediatric patient with relapsed …

S Saito, R Yanagisawa, K Yoshikawa, Y Higuchi… - Cytotherapy, 2015 - Elsevier
A 15-year-old girl with acute lymphoblastic leukemia received allogeneic dendritic cell
vaccination, pulsed with Wilms tumor 1 (WT1) peptide, after her third hematopoietic stem cell …

Outcomes in children with hemophagocytic lymphohistiocytosis treated using HLH-2004 protocol in Japan

R Yanagisawa, Y Nakazawa, K Matsuda… - International journal of …, 2019 - Springer
Recent advances in intensive chemo- and immunotherapy have contributed to the outcome
of hemophagocytic lymphohistiocytosis (HLH); however, the prognosis of HLH in children …