Lymphatic vessels develop from specialized endothelial cells in preexisting blood vessels,
but the molecular signals that regulate this separation are unknown. Here we identify a failure …

We describe how to convert the heuristic search algorithm A* into an anytime algorithm that
finds a sequence of improved solutions and eventually converges to an optimal solution. The …

Recent work shows that the memory requirements of A* and related graph-search algorithms
can be reduced substantially by only storing nodes that are on or near the search frontier, …

Traditional Chinese medicine (TCM) is not only an effective solution for primary health care,
but also a great resource for drug innovation and discovery. To meet the increasing needs …

Background Non-alcoholic steatohepatitis (NASH) is characterised by hepatic steatosis,
inflammation, hepatocellular injury, and progressive liver fibrosis. Resmetirom (MGL-3196) is a …

Chimeric proteins joining the histone methyltransferase MLL with various fusion partners
trigger distinctive lymphoid and myeloid leukemias. Here, we immunopurified proteins …

Recording runtime status via logs is common for almost computer system, and detecting
anomalies in logs is crucial for timely identifying malfunctions of systems. However, manually …

Activation of multiple pathways is associated with cardiac hypertrophy and heart failure.
Repression of antihypertrophic pathways has rarely been demonstrated to cause cardiac …

The structural integrity of the heart is maintained by the end-to-end connection between the
myocytes called the intercalated disc. The intercalated disc contains different junctional …

Background Abiotic stresses due to environmental factors could adversely affect the growth
and development of crops. Among the abiotic stresses, drought and heat stress are two …