A herpes simplex virus type 1 function continuously required for early and late virus RNA synthesis

RJ Watson, JB Clements - Nature, 1980 - nature.com
Controlled transcription of animal virus DNAs provides potentially useful models for
elucidating the mechanisms which regulate eukaryotic gene expression. The progressive …

E2F mediates cell cycle-dependent transcriptional repression in vivo by recruitment of an HDAC1/mSin3B corepressor complex

…, JH Dannenberg, S Catchpole, RJ Watson… - Genes & …, 2002 - genesdev.cshlp.org
Despite biochemical and genetic data suggesting that E2F and pRB (pocket protein) families
regulate transcription via chromatin-modifying factors, the precise mechanisms underlying …

An E2F‐binding site mediates cell‐cycle regulated repression of mouse B‐myb transcription.

EW Lam, RJ Watson - The EMBO journal, 1993 - embopress.org
Transcription of the B‐myb gene is regulated at the G1/S boundary of the cell cycle. To
begin to examine the mechanism controlling expression of this gene during the cell‐cycle, a …

Herpes Simplex Virus Type-1 Glycoprotein D Gene: Nucleotide Sequence and Expression in Escherichia coli

RJ Watson, JH Weis, JS Salstrom, LW Enquist - Science, 1982 - science.org
The protein coding region of the herpes simplex virus type-1 glycoprotein D (gD) gene was
mapped, and the nucleotide sequence was determined. The predicted amino acid sequence …

Binding of FoxM1 to G2/M gene promoters is dependent upon B-Myb

CF Down, J Millour, EWF Lam, RJ Watson - Biochimica Et Biophysica Acta …, 2012 - Elsevier
The promoters of genes which regulate entry into and progress through mitosis are typically
induced maximally in G2 by transcription factors that include B-Myb and FoxM1. As FoxM1 …

Temporal regulation of herpes simplex virus type 1 transcription: location of transcripts on the viral genome

JB Clements, RJ Watson, NM Wilkie - Cell, 1977 - cell.com
Nuclear and cytoplasmic viral RNAs, synthesized in cells productively infected with herpes
simplex virus type 1 at early and late times post-infection and in the presence of DNA and …

Activation of human B-MYB by cyclins

…, MG Paggi, A Giordano, RJ Watson… - Proceedings of the …, 1997 - National Acad Sciences
B-MYB expression is associated with cell proliferation and recent studies have suggested
that it promotes the S phase of mammalian cells. Based on its homology to the transcription …

Effect of selective decontamination of the digestive tract on hospital mortality in critically ill patients receiving mechanical ventilation: a randomized clinical trial

…, J O'Donnell, J Watson, S Bihari, J Brown… - Jama, 2022 - jamanetwork.com
… the 95% CI, adjusted by the Kenward-Roger correction. Prespecified sensitivity analyses
were conducted without the Kenward-Roger correction and by fitting a linear regression at the …

Nucleotide preferences in sequence-specific recognition of DNA by c-myb protein

KM Howe, RJ Watson - Nucleic acids research, 1991 - academic.oup.com
Using a binding site selection procedure, we have found that sequence-specific DNA-binding
by the mouse c-myb protein involves recognition of nucleotides outside of the previously …

[HTML][HTML] De novo design of high-affinity binders of bioactive helical peptides

…, J Nivala, L Stewart, JL Watson, JM Rogers… - Nature, 2024 - nature.com
Many peptide hormones form an α-helix on binding their receptors 1 , 2 , 3 – 4 , and sensitive
methods for their detection could contribute to better clinical management of disease 5 . De …