Genetic alterations in tumor cells often lead to the emergence of growth-stimulatory
autocrine and paracrine signals, involving overexpression of secreted peptide growth factors, …

Epigenetic silencing can mimic genetic mutation by abolishing expression of a gene. We
hypothesized that an epimutation could occur in any gene as a germline event that predisposes …

<p id="p001">Persons who have hypermethylation of one allele of <italic>MLH1</italic> in
somatic cells throughout the body (a germ-line epimutation) have a predisposition for the …

The contribution of whole-genome doubling to chromosomal instability (CIN) and tumor
evolution is unclear. We use long-term culture of isogenic tetraploid cells from a stable diploid …

Off‐label prescribing is the prescription of a registered medicine for a use that is not included
in the product information. The practice is common, with rates up to 40% in adults and up to …

Activation of the canonical TGF-β signaling pathway provides growth inhibitory signals in
the normal intestinal epithelium. Colorectal cancers (CRCs) frequently harbor somatic …

Purpose: Macrophage inhibitory cytokine-1 (MIC-1) is a divergent member of the tumor growth
factor β (TGF-β) superfamily. Several observations suggest that it plays a role in colorectal …

Aims: To determine the prevalence of colorectal polyps of different types in an unselected
population, and to correlate the morphological diagnoses with BRAF mutation analysis. …

In mammalian genomes, the methylation of cytosine residues within CpG dinucleotides is
crucial to normal development and cell differentiation. However, methylation of cytosines in the …

Multiple genes and their variants that lend susceptibility to many diseases will play a major
role in clinical routine. Genetics-based cost reduction strategies in diagnostic processes are …