Simple Summary Normal epithelial cells in our organs are surrounded by stroma, which is
an ecosystem made up of a variety of cells and proteins that support their intended functions. …

We investigated the capacity of 1,25-dihydroxyvitamin D 3 [1,25(OH) 2 D 3 ] and all-trans-retinoic
acid (ATRA) to sensitize three breast cancer cell lines to the cell killing effects of …

Simple Summary Cancer cells travel to far away parts of the body before the original cancer
can be detected. Breast cancer cells travel mainly to the bone marrow, where they are kept …

Drug repositioning in cancer has been pursued for years because of slowing drug
development, increasing costs, and the availability of drugs licensed for other indications with …

Simple Summary Breast cancer cells travel via the bloodstream to the bone before the
cancer is detectable in the breast. These disseminated cells are resistant to adjuvant …

The mechanisms of long-term survival of occult breast cancer cells in the bone marrow
microenvironment are not known. Using selected bone marrow stromal components with …

Vitamin D 3 derivatives and retinoids can induce cell cycle arrest, differentiation and cell death
in many cell lines. These compounds can act cooperatively in some of their functions and …

Purpose: We investigated a combination therapy with weekly paclitaxel and all trans-retinoic
acid (ATRA) for tolerability, response to treatment, time to progression and survival in …

Background Dormant estrogen receptor positive (ER+) breast cancer micrometastases in
the bone marrow survive adjuvant chemotherapy and recur stochastically for more than 20 …

Basic fibroblast growth factor (bFGF), a classical mitogen in fibroblasts and endothelial cells,
inhibits the proliferation of MCF-7 and other human breast cancer cell lines. To explain this …