[PDF][PDF] Inducible FGFR-1 activation leads to irreversible prostate adenocarcinoma and an epithelial-to-mesenchymal transition
VD Acevedo, RD Gangula, KW Freeman, R Li, Y Zhang… - Cancer cell, 2007 - cell.com
Fibroblast Growth Factor Receptor-1 (FGFR1) is commonly overexpressed in advanced
prostate cancer (PCa). To investigate causality, we utilized an inducible FGFR1 (iFGFR1) …
prostate cancer (PCa). To investigate causality, we utilized an inducible FGFR1 (iFGFR1) …
Cancer-related axonogenesis and neurogenesis in prostate cancer
GE Ayala, H Dai, M Powell, R Li, Y Ding… - Clinical Cancer …, 2008 - AACR
Purpose: Perineural invasion is the only interaction between cancer cells and nerves studied
to date. It is a symbiotic relationship between cancer and nerves that results in growth …
to date. It is a symbiotic relationship between cancer and nerves that results in growth …
The prolyl isomerase Pin1 is a novel prognostic marker in human prostate cancer
Prostate cancer (PCa) is the most common male cancer in the United States. A major
challenge that remains is to predict the clinical outcome in managing PCa patients. The prolyl …
challenge that remains is to predict the clinical outcome in managing PCa patients. The prolyl …
Growth and survival mechanisms associated with perineural invasion in prostate cancer
Perineural invasion (PNI) is the major mechanism of prostate cancer spread outside the
prostate. Apoptotic and proliferation indices were determined in PNI cells using the PNI in vitro …
prostate. Apoptotic and proliferation indices were determined in PNI cells using the PNI in vitro …
High levels of phosphorylated form of Akt-1 in prostate cancer and non-neoplastic prostate tissues are strong predictors of biochemical recurrence
G Ayala, T Thompson, G Yang, A Frolov, R Li… - Clinical Cancer …, 2004 - AACR
Akt is a serine-threonine-kinase that phosphorylates proteins in several pathways regulating
aspects of metabolism, apoptosis, and proliferation. Akt signaling promotes proliferation …
aspects of metabolism, apoptosis, and proliferation. Akt signaling promotes proliferation …
High level of androgen receptor is associated with aggressive clinicopathologic features and decreased biochemical recurrence-free survival in prostate: cancer …
R Li, T Wheeler, H Dai, A Frolov… - The American journal …, 2004 - journals.lww.com
Background: Prostate cancer (PCa) is androgen dependent and is regulated by androgen/androgen
receptor (AR) signaling pathway. However, the clinical significance of AR is in …
receptor (AR) signaling pathway. However, the clinical significance of AR is in …
Targeting Aurora kinases for the treatment of prostate cancer
ECY Lee, A Frolov, R Li, G Ayala, NM Greenberg - Cancer research, 2006 - AACR
Inappropriate expression of the Aurora kinases can induce aberrant mitosis, centrosome
irregularities, and chromosomal instability, which lead to anueploidy and cell transformation. …
irregularities, and chromosomal instability, which lead to anueploidy and cell transformation. …
Global gene expression analysis of reactive stroma in prostate cancer
Purpose: Marked reactive stroma formation, designated as grade 3 reactive stroma, is associated
with poor outcome in clinically localized prostate cancer. To understand the biological …
with poor outcome in clinically localized prostate cancer. To understand the biological …
Decreased expression and androgen regulation of the tumor suppressor gene INPP4B in prostate cancer
MC Hodgson, L Shao, A Frolov, R Li, LE Peterson… - Cancer research, 2011 - AACR
Patients with metastatic prostate cancer who undergo androgen-ablation therapy invariably
relapse and develop incurable castration-resistant disease. Activation of the prosurvival Akt …
relapse and develop incurable castration-resistant disease. Activation of the prosurvival Akt …
Loss of caveolin‐1 in prostate cancer stroma correlates with reduced relapse‐free survival and is functionally relevant to tumour progression
Levels of caveolin‐1 (Cav‐1) in tumour epithelial cells increase during prostate cancer
progression. Conversely, Cav‐1 expression in the stroma can decline in advanced and …
progression. Conversely, Cav‐1 expression in the stroma can decline in advanced and …