AT1 Receptor Agonistic Antibodies From Preeclamptic Patients Stimulate NADPH Oxidase

R Dechend, C Viedt, DN Müller, B Ugele… - Circulation, 2003 - Am Heart Assoc
Background— We recently identified agonistic autoantibodies directed against the angiotensin
AT1 receptor (AT 1 -AA) in the plasma of preeclamptic women. To elucidate their role …

Regulatory T cells ameliorate angiotensin II–induced cardiac damage

…, R Plehm, M Wellner, S Elitok, P Gratze, R Dechend… - Circulation, 2009 - Am Heart Assoc
Background— Hypertensive target organ damage, especially cardiac hypertrophy with heart
failure and arrhythmia, is a major source of morbidity and mortality. Angiotensin II, a major …

Salt-responsive gut commensal modulates TH17 axis and disease

…, C Wu, JM Titze, J Jantsch, M Boschmann, R Dechend… - Nature, 2017 - nature.com
A Western lifestyle with high salt consumption can lead to hypertension and cardiovascular
disease. High salt may additionally drive autoimmunity by inducing T helper 17 (T H 17) cells…

[HTML][HTML] Angiotensin II type 1–receptor activating antibodies in renal-allograft rejection

…, M Nieminen-Kelhä, R Dechend… - … England Journal of …, 2005 - Mass Medical Soc
Background Antibodies against HLA antigens cause refractory allograft rejection with
vasculopathy in some, but not all, patients. Methods We studied 33 kidney-transplant recipients …

Agonistic autoantibodies to the AT1 receptor in a transgenic rat model of preeclampsia

R Dechend, P Gratze, G Wallukat, E Shagdarsuren… - …, 2005 - Am Heart Assoc
We used rats transgenic for the human angiotensinogen (hAogen) gene and the human renin
(hRen) gene and crossed the strains to produce a model of preeclampsia in the dams. The …

Hypertension in pregnancy: diagnosis, blood pressure goals, and pharmacotherapy: a scientific statement from the American Heart Association

VD Garovic, R Dechend, T Easterling… - …, 2022 - Am Heart Assoc
Hypertensive disorders of pregnancy (HDP) remain one of the major causes of pregnancy-related
maternal and fetal morbidity and mortality worldwide. Affected women are also at …

Short-chain fatty acid propionate protects from hypertensive cardiovascular damage

…, A Kushugulova, KU Eckardt, R Dechend… - Circulation, 2019 - Am Heart Assoc
Background: Arterial hypertension and its organ sequelae show characteristics of T cell–mediated
inflammatory diseases. Experimental anti-inflammatory therapies have been shown to …

NF-κB inhibition ameliorates angiotensin II–induced inflammatory damage in rats

DN Muller, R Dechend, EMA Mervaala, JK Park… - …, 2000 - Am Heart Assoc
We recently reported that the activation of nuclear factor-κB (NF-κB) promotes inflammation
in rats harboring both human renin and angiotensinogen genes (double-transgenic rats […

Oxidative stress and preeclampsia: rationale for antioxidant clinical trials

MTM Raijmakers, R Dechend, L Poston - Hypertension, 2004 - Am Heart Assoc
Preeclampsia remains a frequent and potentially dangerous complication of pregnancy. The
cause remains largely unknown, but oxidative stress and a generalized inflammatory state …

[HTML][HTML] Arachidonic acid-metabolizing cytochrome P450 enzymes are targets of ω-3 fatty acids

…, K Blossey, G Wallukat, R Fischer, R Dechend… - Journal of Biological …, 2010 - ASBMB
Eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) protect against cardiovascular
disease by largely unknown mechanisms. We tested the hypothesis that EPA and DHA …