Resveratrol and its analogs: defense against cancer, coronary disease and neurodegenerative maladies or just a fad?

P Saiko, A Szakmary, W Jaeger, T Szekeres - Mutation Research/Reviews …, 2008 - Elsevier
Resveratrol (3,5,4′-trihydroxy-trans-stilbene; RV), a dietary constituent found in grapes and
wine, exerts a wide variety of pharmacological activities. Because the grape skins are not …

Resveratrol analogues as selective cyclooxygenase-2 inhibitors: synthesis and structure–activity relationship

…, N Handler, T Erker, K Pleban, G Ecker, P Saiko… - Bioorganic & medicinal …, 2004 - Elsevier
Resveratrol (3,5,4′-trihydroxy-trans-stilbene) is found in grapes and various medical plants.
Among cytotoxic, antifungal, antibacterial cardioprotective activity resveratrol also …

Gallic acid inhibits ribonucleotide reductase and cyclooxygenases in human HL-60 promyelocytic leukemia cells

S Madlener, C Illmer, Z Horvath, P Saiko, A Losert… - Cancer letters, 2007 - Elsevier
Gallic acid (GA) is a naturally occurring polyhydroxyphenolic compound and an excellent
free radical scavenger. In this study, we examined its cytotoxic and biochemical effects on the …

Resveratrol and resveratrol analogues—structure—activity relationship

T Szekeres, M Fritzer-Szekeres, P Saiko… - Pharmaceutical …, 2010 - Springer
Resveratrol (3,4′,5-trihydroxy-trans-stilbene) is a compound found in wine and is held
responsible for a number of beneficial effects of red wine. Besides the prevention of heart …

Chemopreventive effects of resveratrol and resveratrol derivatives

T Szekeres, P Saiko, M Fritzer‐Szekeres… - Annals of the New …, 2011 - Wiley Online Library
Resveratrol is considered to have a number of beneficial effects. Recently, our group modified
the molecule and synthesized a number of compounds with different biochemical effects. …

Antioxidant activity of resveratrol, piceatannol and 3, 3', 4, 4', 5, 5'-hexahydroxy-trans-stilbene in three leukemia cell lines

Z Ovesná, K Kozics, Y Bader, P Saiko… - Oncology …, 2006 - spandidos-publications.com
trans-Resveratrol (t-RES) is one of the most relevant and extensively investigated stilbenes
with a broad spectrum of biological activities. In contrast to the detailed knowledge of t-RES …

Gallic acid improves health‐associated biochemical parameters and prevents oxidative damage of DNA in type 2 diabetes patients: Results of a placebo‐controlled …

…, H Al‐Serori, M Mišík, P Saiko… - Molecular nutrition & …, 2018 - Wiley Online Library
Scope Oxidative imbalance plays a key role in cancer induction and cardiovascular diseases
(CVD) in patients with type 2 diabetes mellitus (T2DM). The aim of this study is to find out if …

Design, synthesis and anticancer activity of piperazine hydroxamates and their histone deacetylase (HDAC) inhibitory activity

…, M Bunha, M Jagrat, BN Sinha, P Saiko… - Bioorganic & medicinal …, 2010 - Elsevier
Six compounds were synthesized with piperazine in linker region and hydroxamate as Zinc
Binding Group (ZBG). They were screened against three cancer cell-lines (NCIH460; …

Effects of heavy water (D2O) on human pancreatic tumor cells

J Hartmann, Y Bader, Z Horvath, P Saiko… - Anticancer …, 2005 - ar.iiarjournals.org
Background: Pancreatic cancer constitutes an entity which is difficult to treat and, therefore,
mostly fatal. Since heavy water (deuterium oxide, D 2 O) was shown to be active in various …

Epigallocatechin gallate, ellagic acid, and rosmarinic acid perturb dNTP pools and inhibit de novo DNA synthesis and proliferation of human HL-60 promyelocytic …

P Saiko, MT Steinmann, H Schuster, G Graser… - Phytomedicine, 2015 - Elsevier
Epigallocatechin gallate (EGCG), ellagic acid (EA) and rosmarinic acid (RA) are natural
polyphenols exerting cancer chemopreventive effects. Ribonucleotide reductase (RR; EC 1.17.…