Genomic instability promotes tumorigenesis and can occur through various mechanisms,
including defective segregation of chromosomes or inactivation of DNA mismatch repair 1 . …

Acquired hemophilia A (AHA) is caused by autoantibodies against factor VIII (FVIII).
Immunosuppressive treatment (IST) results in remission of disease in 60% to 80% of patients over a …

This is the first precision medicine trial using a functional assay to instruct n-of-one therapies
in oncology. It illustrates that for patients lacking standard therapies, high-content assay-…

The cyclin D1 gene is overexpressed in human breast cancers and is required for oncogene-induced
tumorigenesis. Peroxisome proliferator-activated receptor γ (PPARγ) is a nuclear …

The cyclin D1 gene encodes the regulatory subunit of a holoenzyme that phosphorylates and
inactivates the retinoblastoma protein, thereby promoting cell-cycle progression. Cyclin D1 …

Acute graft-versus-host disease (aGvHD) is a serious complication of allogeneic hematopoietic
stem cell transplantation (allo-HSCT). 1 Although aGvHD of any target organ represents …

Lef/Tcf proteins belong to a family of architectural transcription factors that control developmental
processes and play an important role in oncogenesis. Classical activators of Lef/Tcf-…

In recent years galactomannan antigen testing (GM) and also Aspergillus PCR have become
increasingly important for diagnosis of invasive aspergillosis (IA). Whether or not these …

Purpose: As chemotherapy has not been exten-sively studied in patients with lymphoma of
the mucosa-associated lymphoid tissue (MALT), we initiated a prospective study to evaluate …

Background Aspergillus spp. induce elevated levels of several cytokines. It remains
unknown whether these cytokines hold value for clinical routine and enhance diagnostic …