The class of steroid-like compounds designated cardiac glycosides includes well-known
drugs such as digoxin, digitoxin, and ouabain. Their continued efficacy in treatment of …

Chemical constituents of various tissues of turmeric (Curcuma longa L.) have been
extensively investigated. To date, at least 235 compounds, primarily phenolic compounds and …

Adoptive T cell therapy (ACT) produces durable responses in some cancer patients; however,
most tumors are refractory to ACT and the molecular mechanisms underlying resistance …

Elevated circulating estrogen levels are associated with increased risk of breast cancer in
obese postmenopausal women. Following menopause, the biosynthesis of estrogens through …

Purpose Many cancer centers offer acupuncture services. To date, a comprehensive
systematic review of acupuncture in cancer care has not been conducted. The purpose of this …

Histone modifications, such as the frequently occurring lysine succinylation 1 , 2 , are central
to the regulation of chromatin-based processes. However, the mechanism and functional …

BACKGROUND: Huachansu, a Chinese medicine that comes from dried toad venom from
the skin glands of Bufo gargarizans or B. melanostictus, has been used in the treatment of …

Purpose: Selective cyclooxygenase-2 (COX-2) inhibitors may suppress carcinogenesis by
both COX-2-dependent and COX-2-independent mechanisms. The primary purpose of this …

Background: Nonsteroidal anti-inflammatory drugs (NSAIDs) appear to act via induction of
apoptosis—programmed cell death—as potential colorectal cancer chemopreventive agents. …

The inducible prostaglandin synthase cyclooxygenase-2 (Cox-2) is overexpressed in ∼40%
of human breast cancers and at higher frequencies in preinvasive ductal carcinoma in situ (…