Alterations in significant genes located on chromosome 7-including epidermal growth factor
receptor (EGFR) and also v-Raf murine sarcoma viral oncogene homolog B (BRAF) as a …

Purpose: Although findings in human studies trying to identify signs of cochlear
synaptopathy (CS) are still controversial, several methodological restrictions exist, including …

Salivary gland carcinomas belong to the head and neck carcinoma super category of
malignancies. They are characterized by histopathological diversity and comprise a variety of …

Background/Aim: Oncogene up-regulation combined with suppressor gene down-regulation
is a crucial genetic combination that promotes cell neoplastic phenotype and progressively …

Among intra-cellular homeostasis mechanisms, ubiquitination plays a critical role in protein
metabolism regulation by degrading proteins via activating a broad spectrum of ubiquitin …

Thyroid carcinoma represents a leading malignancy among those derived from human
endocrine systems. It comprises a variety of different histological subtypes, including mainly …

Among the tumour suppressor genes that affect critically cell functions and homeostasis,
phosphatase and tensin homolog deleted in chromosome 10 (PTEN-gene locus: 10q21) …

In normal epithelia, proto-oncogenes regulate critical intra-or intercellular functions, including
cell growth and proliferation, apoptosis, and signaling transduction from the cell periphery (…

Head and neck carcinoma (HNC) comprises a variety of pathological entities. Among them,
squamous cell carcinoma (SCC) is histo-pathologically prominent. Specific malignancies, …

Background: Oral squamous cell carcinoma (OSCC) is characterized by a broad spectrum of
genomic imbalances, including gross chromosomal (polysomy/aneuploidy) ones as well as …