Combined targeting of STAT3/NF-κB/COX-2/EP4 for effective management of pancreatic cancer

J Gong, J Xie, R Bedolla, P Rivas, D Chakravarthy… - Clinical Cancer …, 2014 - AACR
Purpose: Near equal rates of incidence and mortality emphasize the need for novel targeted
approaches for better management of patients with pancreatic cancer. Inflammatory …

Dietary resveratrol prevents development of high-grade prostatic intraepithelial neoplastic lesions: involvement of SIRT1/S6K axis

G Li, P Rivas, R Bedolla, D Thapa, RL Reddick… - Cancer prevention …, 2013 - AACR
SIRT1 (mammalian ortholog of the yeast silent information regulator 2) is a NAD-dependent
histone deacetylase belonging to the multigene family of sirtuins. Anecdotal and …

SIRT1 inhibition‐induced senescence as a strategy to prevent prostate cancer progression

SB Huang, P Rivas, X Yang, Z Lai… - Molecular …, 2022 - Wiley Online Library
Emerging evidence suggests an important role for SIRT1, a nicotinamide adenine dinucleotide
(NAD)‐dependent deacetylase in cancer development, progression and therapeutic …

Suppression of ribosomal protein RPS6KB1 by Nexrutine increases sensitivity of prostate tumors to radiation

SS Hussain, SB Huang, RG Bedolla, P Rivas… - Cancer Letters, 2018 - Elsevier
Radiation therapy (XRT) is a standard treatment for prostate cancer (PCa). Although dose
escalation increases local control, toxicity hampers further escalation. Broader improvement …

Phellodendron amurense bark extract prevents progression of prostate tumors in transgenic adenocarcinoma of mouse prostate: potential for prostate cancer …

R Ghosh, H Graham, P Rivas, XJ Tan… - Anticancer …, 2010 - ar.iiarjournals.org
Prostate cancer is the second leading cause of cancer-related deaths in men in Western
society. Epidemiological studies suggest that a reduced risk of cancer is associated with the …

[HTML][HTML] Evidence for 2-methoxyestradiol-mediated inhibition of receptor tyrosine kinase RON in the management of prostate cancer

…, S Jayamohan, P Osmulski, J Xie, P Rivas… - International journal of …, 2021 - mdpi.com
2-Methoxyestradiol (2-ME 2 ) possesses anti-tumorigenic activities in multiple tumor models
with acceptable tolerability profile in humans. Incomplete understanding of the mechanism …

[HTML][HTML] Exercise preserves muscle mass and force in a prostate cancer mouse model

DI Patel, K Abuchowski, B Sheikh, P Rivas… - European Journal of …, 2019 - ncbi.nlm.nih.gov
The purpose of this study was to examine the effects of exercise in modulating biomarkers
of sarcopenia in a treatment naïve transgenic adenocardinoma of the mouse prostate (TRAMP…

[HTML][HTML] Nexrutine and exercise similarly prevent high grade prostate tumors in transgenic mouse model

DI Patel, K Abuchowski, R Bedolla, P Rivas, N Musi… - PLoS …, 2019 - journals.plos.org
The purpose of this investigation was to compare the antitumorigenic effects of the natural
product Nexrutine to voluntary wheel running (VWR) in the transgenic adenocarcinoma of the …

Nexrutine® preserves muscle mass similar to exercise in prostate cancer mouse model

DI Patel, D Wallace, K Abuchowski, P Rivas… - Physiological …, 2019 - Wiley Online Library
Muscle loss is a debilitating side effect to prostate cancer (PCa) experienced by nearly 60%
of men. The purpose of this study was to test the hypothesis that Nexrutine ® , a bark extract …

Transcriptomic evaluation of exercise-induced suppression of prostate cancer aggressiveness

DI Patel, P Rivas, Y Chen, Z Lai, RL Reddick, Y Ikeno… - Cancer Research, 2023 - AACR
Previous studies from our laboratory have showed that aerobic exercise significantly reduced
the number of aggressive poorly differentiated tumors in the transgenic adenocarcinoma of …