The major histocompatibility complex I (MHC-1) presents antigenic peptides to tumor-specific
CD8 + T cells. The regulation of MHC-I by kinases is largely unstudied, even though many …

We have leveraged the molecular characterization of different types of CREBBP mutations
to define a rational approach for targeting these mutations through selective inhibition of …

Although methotrexate (MTX) is the most widely used therapy for central nervous system (CNS)
prophylaxis in patients with diffuse large B-cell lymphoma (DLBCL), the optimal regimen …

The proviral insertion in murine (PIM) lymphoma proteins are a serine/threonine kinase
family composed of three isoformes: Pim-1, Pim-2 and Pim-3. They play a critical role in the …

Cancer anorexia-cachexia syndrome (CACS) is the most frequent paraneoplastic syndrome
occurring in half of all oncologic patients and is considered as a poor prognosticator. …

Despite a characteristic indolent course, a substantial subset of follicular lymphoma (FL)
patients has an early relapse with a poor outcome. Cells in the microenvironment may be a key …

The standard therapies in lymphoma have predominantly focused on targeting tumor cells
with less of a focus on the tumor microenvironment (TME), which plays a critical role in …

Purpose: In RE-MIND2 (NCT04697160), patient-level outcomes from the L-MIND study (NCT02399085)
of tafasitamab plus lenalidomide were retrospectively compared with patient-…

Although the majority of patients with diffuse large B‐cell lymphoma (DLBCL) can be cured
with the standard immunochemotherapy R‐CHOP, one‐third of them relapses with a dismal …

Background Cachexia may occur in 40% of cancer patients, representing the major cause
of death in more than 20% of them. The aim of this study was to investigate the role of leptin, …