Toll-like receptor-4 is a mediator of proliferation in esophageal adenocarcinoma

PD Kohtz, AL Halpern, MA Eldeiry, K Hazel… - The Annals of Thoracic …, 2019 - Elsevier
Background Chronic inflammation from reflux disease has been implicated as part of the
development of esophageal adenocarcinoma. Toll-like receptors (TLRs), a component of the …

Clinical predictors of in‐hospital mortality in venoarterial extracorporeal membrane oxygenation

NG Vigneshwar, PD Kohtz, MT Lucas… - Journal of cardiac …, 2020 - Wiley Online Library
Introduction Venoarterial extracorporeal membrane oxygenation (VA‐ECMO) is utilized as a
life‐saving procedure and bridge to myocardial recovery for patients in refractory …

Improved mortality associated with the use of extracorporeal membrane oxygenation

AL Halpern, PD Kohtz, L Helmkamp, M Eldeiry… - The Annals of Thoracic …, 2019 - Elsevier
Background Our objective was to evaluate the association of bridge to transplant (BTT)
extracorporeal membrane oxygenation (ECMO) on survival after lung transplantation (LTx) and …

Activation of toll-like receptor 2 promotes proliferation of human lung adenocarcinoma cells

AK Gergen, PD Kohtz, AL Halpern, A Li… - Anticancer …, 2020 - ar.iiarjournals.org
Background/Aim: The aim of this study was to evaluate the role of toll-like receptor 2 (TLR2)
in the proliferation of human lung cancer cells and identify the signaling pathway that …

Secretory phospholipase A2 IIa mediates expression of growth factor receptors in esophageal adenocarcinoma

AL Halpern, PD Kohtz, AM White, AK Houk… - Digestive diseases and …, 2021 - Springer
Background Receptor tyrosine kinases of the epidermal growth factor receptor (EGFR)
family such as human epidermal receptor-2 (HER2) are involved in the development and …

Aortic arch repair using open and hybrid techniques: a systematic review

OM Sharaf, PD Kohtz, GJ Arnaoutakis - Innovations, 2022 - journals.sagepub.com
Early surgical intervention is critical for treatment of aortic arch aneurysms and dissections,
but limited comprehensive data exist to define the optimal approach for surgical management …

Inhibition of secretory phospholipase A2 IIa attenuates prostaglandin E2-induced invasiveness in lung adenocarcinoma

AL Halpern, PD Kohtz, JY Rove, L Ao, X Meng… - Molecular and cellular …, 2019 - Springer
Secretory phospholipase A2 IIa (sPLA2 IIa) catalyzes the production of multiple inflammatory
mediators that influence the development of lung and other cancers. The most potent of …

Statins Inhibit Toll-Like Receptor 4–Mediated Growth of Human Esophageal Adenocarcinoma Cells

AK Gergen, PD Kohtz, AL Halpern, AM White… - Journal of Surgical …, 2021 - Elsevier
Background Esophageal adenocarcinoma (EAC) is a lethal malignancy with poor prognosis.
Pharmacologic inhibitors of inflammation, such as statins, have been shown to decrease …

Postoperative complications are not elevated in well-compensated ESRD patients undergoing cardiac surgery: end-stage renal disease cardiac surgery outcomes

BR Griffin, PD Kohtz, M Bronsert, TB Reece… - Journal of Surgical …, 2020 - Elsevier
Background Patients with end-stage renal disease (ESRD) are at high risk for cardiac disease
requiring surgery, and have been shown to have increased surgical risks. There have …

Clinical Predictors of In-Hospital Mortality and Overall Survival for Venoarterial Extracorporeal Membrane Oxygenation in Patients with Refractory Cardiogenic Shock

PD Kohtz, MT Lucas, M Bronsert… - Journal of the …, 2018 - journals.lww.com
METHODS: From 2013 to 2017, 120 patients with cardiogenic shock underwent VA-ECMO.
The etiologies of cardiogenic shock included post-cardiotomy 32 (26%), acute MI 27 (22%), …