Oncogenic KRAS-driven metabolic reprogramming in pancreatic cancer cells utilizes cytokines from the tumor microenvironment
…, P Denz, V Bernard, EY Yen, G Genovese, P Gulhati… - Cancer discovery, 2020 - AACR
Type II cytokines, secreted by Th2 cells in the tumor microenvironment, can stimulate cancer
cell–intrinsic MYC transcriptional upregulation to drive glycolysis. This KRAS*-driven …
cell–intrinsic MYC transcriptional upregulation to drive glycolysis. This KRAS*-driven …
mTORC1 and mTORC2 regulate EMT, motility, and metastasis of colorectal cancer via RhoA and Rac1 signaling pathways
Activation of phosphoinositide 3-kinase (PI3K)/Akt signaling is associated with growth and
progression of colorectal cancer (CRC). We have previously shown that the mTOR kinase, a …
progression of colorectal cancer (CRC). We have previously shown that the mTOR kinase, a …
Targeting T cell checkpoints 41BB and LAG3 and myeloid cell CXCR1/CXCR2 results in antitumor immunity and durable response in pancreatic cancer
Pancreatic ductal adenocarcinoma (PDAC) is considered non-immunogenic, with trials
showing its recalcitrance to PD1 and CTLA4 immune checkpoint therapies (ICTs). Here, we …
showing its recalcitrance to PD1 and CTLA4 immune checkpoint therapies (ICTs). Here, we …
mTOR inhibitors in cancer therapy
YY Zaytseva, JD Valentino, P Gulhati, BM Evers - Cancer letters, 2012 - Elsevier
The mammalian target of rapamycin (mTOR) plays a key role in regulation of cellular metabolism,
growth, and proliferation. The frequent hyperactivation of mTOR signaling makes it an …
growth, and proliferation. The frequent hyperactivation of mTOR signaling makes it an …
Novel expression patterns of PI3K/Akt/mTOR signaling pathway components in colorectal cancer
SM Johnson, P Gulhati, BA Rampy, Y Han… - Journal of the American …, 2010 - Elsevier
BACKGROUND: The phosphatidylinositol 3-kinase/Akt/mammalian target of rapamycin (PI3K/Akt/mTOR)
pathway plays a critical role in the growth and progression of colorectal cancer (…
pathway plays a critical role in the growth and progression of colorectal cancer (…
Akt2 overexpression plays a critical role in the establishment of colorectal cancer metastasis
PG Rychahou, JH Kang, P Gulhati… - Proceedings of the …, 2008 - National Acad Sciences
Colorectal cancer is the second leading cause of cancer-related deaths in the United States.
Understanding the distinct genetic and epigenetic changes contributing to the …
Understanding the distinct genetic and epigenetic changes contributing to the …
Curcumin inhibits proliferation of colorectal carcinoma by modulating Akt/mTOR signaling
SM Johnson, PAT Gulhati, I Arrieta, X Wang… - Anticancer …, 2009 - ar.iiarjournals.org
Background: Curcumin, a natural polyphenol product of the plant Curcuma longa, has been
shown to inhibit the growth and progression of colorectal cancer; however, the anticancer …
shown to inhibit the growth and progression of colorectal cancer; however, the anticancer …
Inhibition of fatty acid synthase attenuates CD44-associated signaling and reduces metastasis in colorectal cancer
YY Zaytseva, PG Rychahou, P Gulhati, VA Elliott… - Cancer research, 2012 - AACR
Fatty acid synthase (FASN) and ATP-citrate lyase, key enzymes of de novo lipogenesis, are
significantly upregulated and activated in many cancers and portend poor prognosis. Even …
significantly upregulated and activated in many cancers and portend poor prognosis. Even …
Targeted inhibition of mammalian target of rapamycin signaling inhibits tumorigenesis of colorectal cancer
P Gulhati, Q Cai, J Li, J Liu, PG Rychahou, S Qiu… - Clinical cancer …, 2009 - AACR
Purpose: The mammalian target of rapamycin (mTOR) kinase acts downstream of phosphoinositide
3-kinase/Akt to regulate cellular growth, metabolism, and cytoskeleton. Because ∼…
3-kinase/Akt to regulate cellular growth, metabolism, and cytoskeleton. Because ∼…
The deubiquitination enzyme USP46 functions as a tumor suppressor by controlling PHLPP-dependent attenuation of Akt signaling in colon cancer
X Li, PD Stevens, H Yang, P Gulhati, W Wang… - Oncogene, 2013 - nature.com
PH domain leucine-rich-repeats protein phosphatase (PHLPP) is a family of Ser/Thr protein
phosphatases that serve as tumor suppressors by negatively regulating Akt. Our recent …
phosphatases that serve as tumor suppressors by negatively regulating Akt. Our recent …