Biomedical applications of nisin

JM Shin, JW Gwak, P Kamarajan… - Journal of applied …, 2016 - academic.oup.com
Nisin is a bacteriocin produced by a group of Gram‐positive bacteria that belongs to
Lactococcus and Streptococcus species. Nisin is classified as a Type A (I) lantibiotic that is …

Nisin, an apoptogenic bacteriocin and food preservative, attenuates HNSCC tumorigenesis via CHAC 1

NE Joo, K Ritchie, P Kamarajan, D Miao… - Cancer …, 2012 - Wiley Online Library
Nisin, a bacteriocin and commonly used food preservative, may serve as a novel potential
therapeutic for treating head and neck squamous cell carcinoma ( HNSCC ), as it induces …

Association between metabolic syndrome and periodontitis: The role of lipids, inflammatory cytokines, altered host response, and the microbiome

…, JM Shin, T Chen, JC Fenno, P Kamarajan… - Periodontology …, 2021 - Wiley Online Library
Periodontitis has been associated with many systemic diseases and conditions, including
metabolic syndrome. Metabolic syndrome is a cluster of conditions that occur concomitantly …

Sirtuin‐3 (SIRT3), a novel potential therapeutic target for oral cancer

TY Alhazzazi, P Kamarajan, N Joo, JY Huang… - Cancer, 2011 - Wiley Online Library
BACKGROUND: Several sirtuin family members (SIRT1‐7), which are evolutionarily conserved
NAD‐dependent deacetylases, play an important role in carcinogenesis. However, their …

[HTML][HTML] SIRT3 and cancer: tumor promoter or suppressor?

TY Alhazzazi, P Kamarajan, E Verdin… - Biochimica et Biophysica …, 2011 - Elsevier
Sirtuins (SIRT1–7), the mammalian homologues of the Sir2 gene in yeast, have emerging
roles in age-related diseases, such as cardiac hypertrophy, diabetes, obesity, and cancer. …

[HTML][HTML] Nisin ZP, a bacteriocin and food preservative, inhibits head and neck cancer tumorigenesis and prolongs survival

P Kamarajan, T Hayami, B Matte, Y Liu, T Danciu… - PloS one, 2015 - journals.plos.org
The use of small antimicrobial peptides or bacteriocins, like nisin, to treat cancer is a new
approach that holds great promise. Nisin exemplifies this new approach because it has been …

[HTML][HTML] Periodontal pathogens promote cancer aggressivity via TLR/MyD88 triggered activation of Integrin/FAK signaling that is therapeutically reversible by a …

P Kamarajan, I Ateia, JM Shin, JC Fenno, C Le… - PLoS …, 2020 - journals.plos.org
Epidemiological studies reveal significant associations between periodontitis and oral cancer.
However, knowledge about the contribution of periodontal pathogens to oral cancer and …

Magic angle spinning NMR-based metabolic profiling of head and neck squamous cell carcinoma tissues

BS Somashekar, P Kamarajan, T Danciu… - Journal of proteome …, 2011 - ACS Publications
High-resolution magic-angle spinning (HR-MAS) proton NMR spectroscopy is used to
explore the metabolic signatures of head and neck squamous cell carcinoma (HNSCC) which …

Delineating metabolic signatures of head and neck squamous cell carcinoma: phospholipase A2, a potential therapeutic target

P Tripathi, P Kamarajan, BS Somashekar… - The international journal …, 2012 - Elsevier
A better understanding of molecular pathways involved in malignant transformation of head
and neck squamous cell carcinoma (HNSCC) is essential for the development of novel and …

[HTML][HTML] Microbial Communities Associated with Primary and Metastatic Head and Neck Squamous Cell Carcinoma – A High Fusobacterial and Low Streptococcal …

JM Shin, T Luo, P Kamarajan, JC Fenno, AH Rickard… - Scientific reports, 2017 - nature.com
Given the potential relationship between head and neck squamous cell carcinoma (HNSCC)
and microbial dysbiosis, we profiled the microbiome within healthy normal and tumorous (…