Gastrointestinal stromal tumors (GISTs) are mesenchymal neoplasms driven by oncogenic,
mutational activation of KIT or platelet-derived growth factor receptor α (PDGFRA). GIST-…

Undifferentiated gastrointestinal tract carcinomas are rare highly aggressive neoplasms with
frequent but not obligatory rhabdoid features. Recent studies showed loss of SMARCB1 (…

This study was undertaken to determine the frequency, and the clinicopathologic and genetic
features, of colon cancers driven by neurotrophic receptor tyrosine kinase (NTRK) gene …

Biphasic squamoid alveolar renal cell carcinoma (BSARCC) has been recently described
as a distinct neoplasm. Twenty-one cases from 12 institutions were analyzed using routine …

Oncogenic gene fusions represent attractive targets for therapy of cancer. However, the
frequency of actionable genomic rearrangements in colorectal cancer (CRC) is very low, and …

PURPOSE Analysis of somatic variant profiles in retrospectively collected pairs of primary
tumors and synchronous liver metastases from surgically treated patients with colorectal …

t(6;11) renal cell carcinoma (RCC) has been recognized as a rare and mostly nonaggressive
tumor (NAT). The criteria for distinguishing aggressive tumors (AT) from NATs are not well …

Background Hepatocellular carcinoma (HCC) is a fatal disease characterized by early
genetic alterations in telomerase reverse transcriptase promoter (TERTp) and β-catenin (CTNNB1…

Eighteen cases of Vanek’s tumors are presented. The patients included nine men and nine
women between the ages of 45 and 93 years (mean, 66.2 years). Nine cases were clinically …

Sir, mesenchymal tumors of the pancreas are exceedingly rare, accounting for less than 1%
of all pancreatic tumors, and most of them have been reported in small series or as single …