The emerging role of EpCAM in cancer and stem cell signaling

M Munz, PA Baeuerle, O Gires - Cancer research, 2009 - AACR
Initially discovered as a dominant antigen on colon carcinomas, the epithelial cell adhesion
molecule (EpCAM) was considered a mere cell adhesion molecule and reliable surface-…

Nuclear signalling by tumour-associated antigen EpCAM

…, C Kieu, P Papior, PA Baeuerle, M Munz, O Gires - Nature cell …, 2009 - nature.com
EpCAM was found to be overexpressed on epithelial progenitors, carcinomas and cancer-initiating
cells. The role of EpCAM in proliferation, and its association with cancer is poorly …

The carcinoma-associated antigen EpCAM upregulates c-myc and induces cell proliferation

M Münz, C Kieu, B Mack, B Schmitt, R Zeidler, O Gires - Oncogene, 2004 - nature.com
Epithelial cell adhesion molecule (EpCAM) is a membrane glycoprotein expressed on
adenomatous and simple epithelia, where it is involved in homophilic adhesion at the basolateral …

[HTML][HTML] EpCAM (CD326) finding its role in cancer

PA Baeuerle, O Gires - British journal of cancer, 2007 - nature.com
Although epithelial cell adhesion/activating molecule (EpCAM/CD326) is one of the first
tumour-associated antigens identified, it has never received the same level of attention as other …

[HTML][HTML] Expression and function of epithelial cell adhesion molecule EpCAM: where are we after 40 years?

O Gires, M Pan, H Schinke, M Canis… - Cancer and Metastasis …, 2020 - Springer
EpCAM (epithelial cell adhesion molecule) was discovered four decades ago as a tumor
antigen on colorectal carcinomas. Owing to its frequent and high expression on carcinomas …

[HTML][HTML] Latent membrane protein 1 of Epstein–Barr virus interacts with JAK3 and activates STAT proteins

O Gires, F Kohlhuber, E Kilger, M Baumann… - The EMBO …, 1999 - embopress.org
Latent membrane protein 1 (LMP1) acts like a permanently activated receptor of the tumor
necrosis factor (TNF)‐receptor superfamily and is absolutely required for B cell …

[HTML][HTML] Latent membrane protein 1 of Epstein–Barr virus mimics a constitutively active receptor molecule

O Gires, U Zimber‐Strobl, R Gonnella, M Ueffing… - The EMBO …, 1997 - embopress.org
Latent membrane protein 1 (LMP1) of Epstein–Barr virus (EBV) is an integral membrane
protein which has transforming potential and is necessary but not sufficient for B‐cell …

Identification and functional analysis of tumor-infiltrating plasmacytoid dendritic cells in head and neck cancer

…, M Wagner, D Wellisch, B Mack, T Giese, O Gires… - Cancer research, 2003 - AACR
The antitumor activity of IFN-α is well established. However, the role of the plasmacytoid
dendritic cell (PDC), the major producer of IFN-α upon viral infection, in tumor biology is …

[HTML][HTML] Epstein–Barr virus latent membrane protein‐1 triggers AP‐1 activity via the c‐Jun N‐terminal kinase cascade

A Kieser, E Kilger, O Gires, M Ueffing, W Kolch… - The EMBO …, 1997 - embopress.org
The Epstein–Barr virus latent membrane protein‐1 (LMP‐1) is an integral membrane protein
which transforms fibroblasts and is essential for EBV‐mediated B‐cell immortalization. LMP‐…

[HTML][HTML] TSPAN8 promotes cancer cell stemness via activation of sonic Hedgehog signaling

R Zhu, O Gires, L Zhu, J Liu, J Li, H Yang, G Ju… - Nature …, 2019 - nature.com
Cancer stem cells (CSCs) represent a major source of treatment resistance and tumor
progression. However, regulation of CSCs stemness is not entirely understood. Here, we report …