The emerging role of EpCAM in cancer and stem cell signaling
M Munz, PA Baeuerle, O Gires - Cancer research, 2009 - AACR
Initially discovered as a dominant antigen on colon carcinomas, the epithelial cell adhesion
molecule (EpCAM) was considered a mere cell adhesion molecule and reliable surface-…
molecule (EpCAM) was considered a mere cell adhesion molecule and reliable surface-…
Nuclear signalling by tumour-associated antigen EpCAM
…, C Kieu, P Papior, PA Baeuerle, M Munz, O Gires - Nature cell …, 2009 - nature.com
EpCAM was found to be overexpressed on epithelial progenitors, carcinomas and cancer-initiating
cells. The role of EpCAM in proliferation, and its association with cancer is poorly …
cells. The role of EpCAM in proliferation, and its association with cancer is poorly …
The carcinoma-associated antigen EpCAM upregulates c-myc and induces cell proliferation
M Münz, C Kieu, B Mack, B Schmitt, R Zeidler, O Gires - Oncogene, 2004 - nature.com
Epithelial cell adhesion molecule (EpCAM) is a membrane glycoprotein expressed on
adenomatous and simple epithelia, where it is involved in homophilic adhesion at the basolateral …
adenomatous and simple epithelia, where it is involved in homophilic adhesion at the basolateral …
[HTML][HTML] EpCAM (CD326) finding its role in cancer
PA Baeuerle, O Gires - British journal of cancer, 2007 - nature.com
Although epithelial cell adhesion/activating molecule (EpCAM/CD326) is one of the first
tumour-associated antigens identified, it has never received the same level of attention as other …
tumour-associated antigens identified, it has never received the same level of attention as other …
[HTML][HTML] Expression and function of epithelial cell adhesion molecule EpCAM: where are we after 40 years?
O Gires, M Pan, H Schinke, M Canis… - Cancer and Metastasis …, 2020 - Springer
EpCAM (epithelial cell adhesion molecule) was discovered four decades ago as a tumor
antigen on colorectal carcinomas. Owing to its frequent and high expression on carcinomas …
antigen on colorectal carcinomas. Owing to its frequent and high expression on carcinomas …
[HTML][HTML] Latent membrane protein 1 of Epstein–Barr virus interacts with JAK3 and activates STAT proteins
O Gires, F Kohlhuber, E Kilger, M Baumann… - The EMBO …, 1999 - embopress.org
Latent membrane protein 1 (LMP1) acts like a permanently activated receptor of the tumor
necrosis factor (TNF)‐receptor superfamily and is absolutely required for B cell …
necrosis factor (TNF)‐receptor superfamily and is absolutely required for B cell …
[HTML][HTML] Latent membrane protein 1 of Epstein–Barr virus mimics a constitutively active receptor molecule
Latent membrane protein 1 (LMP1) of Epstein–Barr virus (EBV) is an integral membrane
protein which has transforming potential and is necessary but not sufficient for B‐cell …
protein which has transforming potential and is necessary but not sufficient for B‐cell …
Identification and functional analysis of tumor-infiltrating plasmacytoid dendritic cells in head and neck cancer
…, M Wagner, D Wellisch, B Mack, T Giese, O Gires… - Cancer research, 2003 - AACR
The antitumor activity of IFN-α is well established. However, the role of the plasmacytoid
dendritic cell (PDC), the major producer of IFN-α upon viral infection, in tumor biology is …
dendritic cell (PDC), the major producer of IFN-α upon viral infection, in tumor biology is …
[HTML][HTML] Epstein–Barr virus latent membrane protein‐1 triggers AP‐1 activity via the c‐Jun N‐terminal kinase cascade
The Epstein–Barr virus latent membrane protein‐1 (LMP‐1) is an integral membrane protein
which transforms fibroblasts and is essential for EBV‐mediated B‐cell immortalization. LMP‐…
which transforms fibroblasts and is essential for EBV‐mediated B‐cell immortalization. LMP‐…
[HTML][HTML] TSPAN8 promotes cancer cell stemness via activation of sonic Hedgehog signaling
R Zhu, O Gires, L Zhu, J Liu, J Li, H Yang, G Ju… - Nature …, 2019 - nature.com
Cancer stem cells (CSCs) represent a major source of treatment resistance and tumor
progression. However, regulation of CSCs stemness is not entirely understood. Here, we report …
progression. However, regulation of CSCs stemness is not entirely understood. Here, we report …