Beta amyloid and hyperphosphorylated tau deposits in the pancreas in type 2 diabetes

…, V Mooser, F Bosman, K Khalili, N Darbinian… - Neurobiology of …, 2010 - Elsevier
Strong epidemiologic evidence suggests an association between Alzheimer disease (AD)
and type 2 diabetes. To determine if amyloid beta (Aβ) and hyperphosphorylated tau occurs in …

Beta-amyloid deposition and Alzheimer's type changes induced by Borrelia spirochetes

…, L Miller, L Forro, R Martins, K Reiss, N Darbinian… - Neurobiology of …, 2006 - Elsevier
The pathological hallmarks of Alzheimer's disease (AD) consist of β-amyloid plaques and
neurofibrillary tangles in affected brain areas. The processes, which drive this host reaction are …

Purα is essential for postnatal brain development and developmentally coupled cellular proliferation as revealed by genetic inactivation in the mouse

…, V Muralidharan, WJ Gault, N Darbinian… - … and cellular biology, 2003 - Taylor & Francis
The single-stranded DNA- and RNA-binding protein, Purα, has been implicated in many
biological processes, including control of transcription of multiple genes, initiation of DNA …

Role of the Agrobacterium tumefaciens VirD2 Protein in T-DNA Transfer and Integration

…, B Bassuner, X Deng, NS Darbinian… - Molecular plant …, 1998 - Am Phytopath Society
VirD2 is one of the key Agrobacterium tumefaciens proteins involved in T-DNA processing
and transfer. In addition to its endonuclease domain, VirD2 contains a bipartite C-terminal …

Diagnostic potential of neural exosome cargo as biomarkers for acute brain injury

L Goetzl, N Merabova, N Darbinian… - Annals of clinical …, 2018 - Wiley Online Library
Objective Neuronal exosomes purified from peripheral blood samples have been proposed
as diagnostic tool in the setting of acute brain injury but never tested clinically. We …

Role of JC virus agnoprotein in DNA repair

…, KM Siddiqui, D Slonina, N Darbinian… - Journal of …, 2004 - Am Soc Microbiol
The late region of human neurotropic JC virus encodes a small 71-amino-acid agnoprotein
that is also found in the polyomaviruses simian virus 40 and BK virus. Several functions of …

Evidence for dysregulation of cell cycle by human polyomavirus, JCV, late auxiliary protein

A Darbinyan, N Darbinian, M Safak, S Radhakrishnan… - Oncogene, 2002 - nature.com
The late region of the human neurotropic JC virus encodes a 71 amino acid protein, named
Agnoprotein, whose biological function remains elusive. Here we demonstrate that in the …

[HTML][HTML] Ethanol-mediated alterations in oligodendrocyte differentiation in the developing brain

N Darbinian, A Darbinyan, N Merabova, A Bajwa… - Neurobiology of …, 2021 - Elsevier
Introduction Alterations of white matter integrity and subsequent white matter structural
deficits are consistent findings in Fetal Alcohol Syndrome (FAS), but knowledge regarding the …

[HTML][HTML] Oligodendrocyte pathology in fetal alcohol spectrum disorders

N Darbinian, ME Selzer - Neural Regeneration Research, 2022 - journals.lww.com
The pathology of fetal alcohol syndrome and the less severe fetal alcohol spectrum
disorders includes brain dysmyelination. Recent studies have shed light on the molecular …

Novel window on early human neurodevelopment via fetal exosomes in maternal blood

L Goetzl, N Darbinian, EJ Goetzl - Annals of Clinical and …, 2016 - Wiley Online Library
Adverse in utero exposures can disrupt fetal brain development, deplete subpopulations of
neurons and inhibit formation of normal synaptic connections. A major roadblock to …