Purpose: To evaluate the activity of CPT-1 1, which is a new derivative of camptothecin,
against refractory or relapsed small-cell lung cancer (SCLC). Patients and Methods: Sixteen …

Purpose This phase III study (V-15-32) compared gefitinib (250 mg/d) with docetaxel (60 mg/m
2 ) in patients (N = 489) with advanced/metastatic non–small-cell lung cancer (NSCLC) …

PURPOSE Camptothecin-11 (CPT-11) is a new semisynthetic derivative of CPT, and has
been shown to inhibit DNA topoisomerase I and to have a strong antitumor activity with low …

This work investigates methods for obtaining reliably clean gold film surfaces. Nine gold
cleaning methods are investigated here: UV ozone photoreactor; potassium hydroxide–…

When dating older sedimentary deposits using quartz, there are no unambiguous methods
for identifying the presence of incomplete bleaching. Current statistical analysis of dose …

Purpose This multicenter, phase II study was conducted to evaluate the activity of amrubicin,
a topoisomerase II inhibitor, against refractory or relapsed small-cell lung cancer (SCLC). …

Purpose: YM155, a novel molecular targeted agent, suppresses survivin, a member of the
inhibitor of apoptosis protein family that is overexpressed in many tumor types. The aim of this …

7-Ethyl-10-[4-(1-piperidino)-1-piperidino]carbonyloxy-camptothecin (CPT-11) is a novel
camptothecin derivative that has been selected for clinical evaluation because of its broad …

To investigate the relationships between the expression of MUC5B and clinicopathological
parameters, the expression of MUC5B was immunohistochemically studied. MUC5B …

Objectives Drug-induced interstitial lung disease (ILD) is often associated with high mortality;
however it is difficult to predict and manage. we examined the clinical findings and imaging …