Redox signal-mediated sensitization of transient receptor potential melastatin 2 (TRPM2) to temperature affects macrophage functions

…, T Uematsu, N Fukuta, N Kobayashi… - Proceedings of the …, 2012 - National Acad Sciences
The ability to sense temperature is essential for organism survival and efficient metabolism.
Body temperatures profoundly affect many physiological functions, including immunity. …

Oral administration of heat-killed Lactobacillus pentosus strain b240 augments protection against influenza virus infection in mice

N Kobayashi, T Saito, T Uematsu, K Kishi… - International …, 2011 - Elsevier
Host-defense mechanisms against influenza virus (IFV) infection involve both innate and
acquired immunities. Among other components, secretory immunoglobulin A (SIgA) in the …

IL-15 is a novel growth factor for murine gamma delta T cells induced by Salmonella infection.

H Nishimura, K Hiromatsu, N Kobayashi… - … (Baltimore, Md.: 1950 …, 1996 - journals.aai.org
We have previously shown evidence for the early recruitment of gamma delta T cells during
the disease course of primary infections with Listeria monocytogenes or Salmonella …

Stratigraphy of the middle-upper Permian and lowermost Triassic at Chaotian, Sichuan, China Record of Late Permian double mass extinction event

…, H Sakai, Z Ji, N Shimizu, N Kobayashi… - Proceedings of the …, 2004 - jstage.jst.go.jp
Precise stratigraphic analysis of Middle-Upper Permian and Lower Triassic sequence at
Chaotian in northern Sichuan, China, identified two remarkable mass extinction horizons, one at …

[HTML][HTML] Prophylactic administration of ivermectin attenuates SARS-CoV-2 induced disease in a Syrian Hamster Model

T Uematsu, T Takano, H Matsui, N Kobayashi… - The Journal of …, 2023 - nature.com
COVID-19, caused by SARS-CoV-2 infection, is currently among the most important public
health concerns worldwide. Although several effective vaccines have been developed, there …

Effect of hot water extract of Chlorella vulgaris on cytokine expression patterns in mice with murine acquired immunodeficiency syndrome after infection with Listeria …

T Hasegawa, Y Kimura, K Hiromatsu, N Kobayashi… - …, 1997 - Elsevier
We have previously reported that oral administration of hot water extract of Chlorella vulgaris
(CVE) enhances resistance to Listeria monocytogenes through augmentation of Listeria-…

Endogenous interleukin 10 prevents apoptosis in macrophages during Salmonella infection

…, H Nishimura, Y Kimura, N Kobayashi… - Biochemical and …, 1995 - Elsevier
To elucidate the biological roles of endogenous interleukin 10 (IL-10) in macrophage
responses during bacterial infection, we examined in vitro effects of neutralizing IL-10 by anti-IL-10 …

IL-10 is involved in the protective effect of dibutyryl cyclic adenosine monophosphate on endotoxin-induced inflammatory liver injury.

T Arai, K Hiromatsu, N Kobayashi… - … (Baltimore, Md.: 1950 …, 1995 - journals.aai.org
The effects of exogenous cAMP, dibutyryl cAMP (DBcAMP) on LPS-induced liver injury
were examined in mice made hypersensitive to LPS by treatment with iv injection of …

[HTML][HTML] Editing DNA methylation in mammalian embryos

…, Y Hatano, R Taniguchi, N Kobayashi… - International journal of …, 2020 - mdpi.com
DNA methylation in mammals is essential for numerous biological functions, such as
ensuring chromosomal stability, genomic imprinting, and X-chromosome inactivation through …

Antimicrobial sesquiterpenoids from Laurus nobilis L.

N Fukuyama, C Ino, Y Suzuki, N Kobayashi… - Natural product …, 2011 - Taylor & Francis
Activity-guided fractionations of leaf extracts from Laurus nobilis L. led to the isolation of a
known sesquiterpene lactone, deacetyl laurenobiolide (1). Compound 1 showed antimicrobial …