User profiles for NORIHIRO YAMAGUCHI

Norihiro Yamaguchi

National Cancer Institute
Verified email at nih.gov
Cited by 2529

Structural, biochemical, and clinical characterization of epidermal growth factor receptor (EGFR) exon 20 insertion mutations in lung cancer

…, S Nakayama, K Ishioka, N Yamaguchi… - Science translational …, 2013 - science.org
Epidermal growth factor receptor (EGFR) gene mutations (G719X, exon 19 deletions/insertions,
L858R, and L861Q) predict favorable responses to EGFR tyrosine kinase inhibitors (TKIs…

Brain metastases in patients with EGFR-mutated or ALK-rearranged non-small-cell lung cancers

D Rangachari, N Yamaguchi, PA VanderLaan, E Folch… - Lung cancer, 2015 - Elsevier
Introduction Brain metastases (BM) are common in non-small-cell lung cancer (NSCLC).
However, the baseline incidence and evolution of BM over time in oncogene-driven NSCLCs …

[PDF][PDF] The cytoplasmic DNA sensor cGAS promotes mitotic cell death

C Zierhut, N Yamaguchi, M Paredes, JD Luo, T Carroll… - Cell, 2019 - cell.com
Pathogenic and other cytoplasmic DNAs activate the cyclic GMP-AMP synthase (cGAS)-stimulator
of interferon genes (STING) pathway to induce inflammation via transcriptional …

[HTML][HTML] Compound EGFR mutations and response to EGFR tyrosine kinase inhibitors

…, AS Bailey, S Nakayama, N Yamaguchi… - Journal of Thoracic …, 2013 - Elsevier
Background: Non–small-cell lung cancers (NSCLCs) containing EGFR mutations are
exquisitely sensitive to epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors (TKIs). …

Success and failure rates of tumor genotyping techniques in routine pathological samples with non-small-cell lung cancer

PA VanderLaan, N Yamaguchi, E Folch, DH Boucher… - Lung cancer, 2014 - Elsevier
Introduction Identification of some somatic molecular alterations in non-small-cell lung
cancer (NSCLC) has become evidence-based practice. The success and failure rate of using …

[PDF][PDF] Functional genomics in vivo reveal metabolic dependencies of pancreatic cancer cells

…, B Prizer, Y Liu, BN Ostendorf, N Yamaguchi… - Cell metabolism, 2021 - cell.com
Pancreatic ductal adenocarcinoma (PDAC) cells require substantial metabolic rewiring to
overcome nutrient limitations and immune surveillance. However, the metabolic pathways …

β-catenin contributes to lung tumor development induced by EGFR mutations

…, Y Hayashi, M Yamamoto, AJ Tan, N Yamaguchi… - Cancer research, 2014 - AACR
The discovery of somatic mutations in EGFR and development of EGFR tyrosine kinase
inhibitors (TKI) have revolutionized treatment for lung cancer. However, resistance to TKIs …

Dual ALK and EGFR inhibition targets a mechanism of acquired resistance to the tyrosine kinase inhibitor crizotinib in ALK rearranged lung cancer

N Yamaguchi, AR Lucena-Araujo, S Nakayama… - Lung cancer, 2014 - Elsevier
Introduction The multitargeted tyrosine kinase inhibitor (TKI) crizotinib is active against ALK
translocated non-small-cell lung cancer (NSCLC); however acquired resistance invariably …

[HTML][HTML] Comparison of cardiac events associated with liposomal doxorubicin, epirubicin and doxorubicin in breast cancer: a Bayesian network meta-analysis

N Yamaguchi, T Fujii, S Aoi, PS Kozuch… - European Journal of …, 2015 - Elsevier
Background Anthracyclines play a broad and important role in the care of patients with either
operable or metastatic breast cancer. However cardiotoxicity narrows the therapeutic index …

PCK1 and DHODH drive colorectal cancer liver metastatic colonization and hypoxic growth by promoting nucleotide synthesis

N Yamaguchi, EM Weinberg, A Nguyen, MV Liberti… - Elife, 2019 - elifesciences.org
Colorectal cancer (CRC) is a major cause of human death. Mortality is primarily due to
metastatic organ colonization, with the liver being the main organ affected. We modeled …