Retracted: genistein mediated histone acetylation and demethylation activates tumor suppressor genes in prostate cancer cells

N Kikuno, H Shiina, S Urakami… - … journal of cancer, 2008 - Wiley Online Library
The above article, published online on 22 April 2008 in Wiley Online Library ( wileyonlinelibrary.com
), has been retracted by agreement between the authors, the journal Editor in Chief, …

Genistein Induces the p21WAF1/CIP1 and p16INK4a Tumor Suppressor Genes in Prostate Cancer Cells by Epigenetic Mechanisms Involving Active Chromatin …

S Majid, N Kikuno, J Nelles, E Noonan, Y Tanaka… - Cancer research, 2008 - AACR
Genistein (4′,5,7-trihydroxyisoflavone) is the most abundant isoflavone found in the soybean.
The effects of genistein on various cancer cell lines have been extensively studied but the …

Epigenetic inactivation of Wnt inhibitory factor-1 plays an important role in bladder cancer through aberrant canonical Wnt/β-catenin signaling pathway

…, LC Li, LA Ribeiro-Filho, M Terashima, N Kikuno… - Clinical Cancer …, 2006 - AACR
Purpose: Aberrant activation of the Wingless-type (Wnt) pathway plays a significant role in
the pathogenesis of several human cancers. Wnt inhibitory factor-1 (Wif-1) was identified as …

Bcl-2 expression as a predictive marker of hormone-refractory prostate cancer treated with taxane-based chemotherapy

T Yoshino, H Shiina, S Urakami, N Kikuno… - Clinical Cancer …, 2006 - AACR
Purpose: Bcl-2 inhibits apoptosis, and its overexpression is associated with hormone
refractory prostate cancer (HRPC). Bak and Bax are in the Bcl-2 family and counteract the …

Combination analysis of hypermethylated Wnt-antagonist family genes as a novel epigenetic biomarker panel for bladder cancer detection

…, K Kawamoto, H Hirata, Y Tanaka, N Kikuno… - Clinical Cancer …, 2006 - AACR
Purpose: Aberrant promoter hypermethylation of Wnt-antagonist genes contributes to the
pathogenesis of several cancers. We hypothesized that combined methylation analysis of Wnt-…

Wnt antagonist DKK1 acts as a tumor suppressor gene that induces apoptosis and inhibits proliferation in human renal cell carcinoma

…, K Nakajima, K Kawamoto, N Kikuno… - … Journal of Cancer, 2011 - Wiley Online Library
The functional significance of Wnt antagonist DKK1 has not been investigated in renal cell
carcinoma (RCC). Therefore, we hypothesized that DKK1 may be a tumor suppressor gene …

Wnt antagonist family genes as biomarkers for diagnosis, staging, and prognosis of renal cell carcinoma using tumor and serum DNA

…, H Hirata, K Kawamoto, T Kawakami, N Kikuno… - Clinical Cancer …, 2006 - AACR
Purpose: We hypothesized that combined methylation analysis of Wnt antagonist genes
could serve as a panel of biomarkers for diagnosis, staging, and prognosis in renal cell …

Expression of the survivin gene in prostate cancer: correlation with clinicopathological characteristics, proliferative activity and apoptosis

H Kishi, M Igawa, N Kikuno, T Yoshino, S Urakami… - The Journal of …, 2004 - Elsevier
PURPOSE: Although survivin expression has been reported in prostate cancer, the clinical
significance of survivin expression remains unclear. To clarify the clinical significance of …

Wnt Antagonist Gene DKK2 Is Epigenetically Silenced and Inhibits Renal Cancer Progression through Apoptotic and Cell Cycle Pathways

…, Y Hinoda, K Nakajima, K Kawamoto, N Kikuno… - Clinical cancer …, 2009 - AACR
Purpose: Wnt/β-catenin signaling is involved in renal cancer. DKK2, a Wnt antagonist, is
silenced in some cancers, although its function has not been investigated. We hypothesized that …

CYP1A1, SULT1A1, and SULT1E1 polymorphisms are risk factors for endometrial cancer susceptibility

…, N Okayama, Y Suehiro, K Kawamoto, N Kikuno… - Cancer, 2008 - Wiley Online Library
BACKGROUND. In estrogen biosynthetic pathways, many enzymes are important for
metabolism, detoxification, and bioavailability. Polymorphisms in these genes may have an effect …