[HTML][HTML] Fenamate NSAIDs inhibit the NLRP3 inflammasome and protect against Alzheimer's disease in rodent models
Non-steroidal anti-inflammatory drugs (NSAIDs) inhibit cyclooxygenase-1 (COX-1) and COX-2
enzymes. The NLRP3 inflammasome is a multi-protein complex responsible for the …
enzymes. The NLRP3 inflammasome is a multi-protein complex responsible for the …
[BOOK][B] At the Heart of the State
… Didier Fassin (1) , Yasmine Bouagga (2) , Isabelle Coutant (2) , Jean-Sébastien Eideliman
(3) , Fabrice Fernandez (2) , Nicolas Fischer (4) , … Nicolas Fischer … IdHAL : nicolas-fischer …
(3) , Fabrice Fernandez (2) , Nicolas Fischer (4) , … Nicolas Fischer … IdHAL : nicolas-fischer …
The flanking regions of PsaD drive efficient gene expression in the nucleus of the green alga Chlamydomonas reinhardtii
N Fischer, JD Rochaix - Molecular Genetics and Genomics, 2001 - Springer
The nuclear gene PsaD encodes an abundant chloroplast protein located on the stromal
side of the Photosystem I complex. We have cloned and sequenced a genomic fragment …
side of the Photosystem I complex. We have cloned and sequenced a genomic fragment …
[HTML][HTML] Vector integration is nonrandom and clustered and influences the fate of lymphopoiesis in SCID-X1 gene therapy
…, B Prum, CC Fraser, N Fischer… - The Journal of …, 2007 - Am Soc Clin Investig
We treated 10 children with X-linked SCID (SCID-X1) using gammaretrovirus-mediated gene
transfer. Those with sufficient follow-up were found to have recovered substantial immunity …
transfer. Those with sufficient follow-up were found to have recovered substantial immunity …
Phytochemicals as inhibitors of NF-κB for treatment of Alzheimer's disease
EJ Seo, N Fischer, T Efferth - Pharmacological research, 2018 - Elsevier
Alzheimer’s disease (AD) is the most prevalent form of dementia. The exact pathophysiology
of this disease remains incompletely understood and safe and effective therapies are …
of this disease remains incompletely understood and safe and effective therapies are …
[HTML][HTML] Arenavirus glycan shield promotes neutralizing antibody evasion and protracted infection
…, MM Remy, P Malinge, G Magistrelli, N Fischer… - PLoS …, 2015 - journals.plos.org
Arenaviruses such as Lassa virus (LASV) can cause severe hemorrhagic fever in humans.
As a major impediment to vaccine development, delayed and weak neutralizing antibody (nAb…
As a major impediment to vaccine development, delayed and weak neutralizing antibody (nAb…
Selectable marker recycling in the chloroplast
N Fischer, O Stampacchia, K Redding… - Molecular and General …, 1996 - Springer
The bacterial geneaadA is an important and widely used selectable marker for manipulation
of the chloroplast genome through biolistic transformation. Because no other such marker is …
of the chloroplast genome through biolistic transformation. Because no other such marker is …
CC chemokine CCL5 plays a central role impacting infarct size and post-infarction heart failure in mice
…, N Vuilleumier, W Ferlin, N Fischer… - European heart …, 2012 - academic.oup.com
Aims The chemokine CCL5 plays a critical role as neutrophil and macrophage activator do
in atherosclerosis and myocardial infarction. Thus, we investigated whether the treatment …
in atherosclerosis and myocardial infarction. Thus, we investigated whether the treatment …
A multi-model assessment of last interglacial temperatures
The last interglaciation (~130 to 116 ka) is a time period with a strong astronomically
induced seasonal forcing of insolation compared to the present. Proxy records indicate a …
induced seasonal forcing of insolation compared to the present. Proxy records indicate a …
Prevention from radiation damage by natural products
N Fischer, EJ Seo, T Efferth - Phytomedicine, 2018 - Elsevier
Background Radiotherapy is a mainstay of cancer treatment since decades. Ionizing radiation
(IR) is used for destruction of cancer cells and shrinkage of tumors. However, the increase …
(IR) is used for destruction of cancer cells and shrinkage of tumors. However, the increase …