Eribulin mesylate (eribulin), an analogue of the marine natural product halichondrin B, is a
microtubule-depolymerizing drug that has utility in the treatment of patients with breast cancer…

The design, synthesis and biological evaluations of fourteen 4-substituted 2,6-dimethylfuro[2,3-d]pyrimidines
are reported. Four compounds (11–13, 15) inhibit vascular endothelial …

The recent shortage of 3,4-methylenedioxymethamphetamine (MDMA, Ecstasy) has led to an
increased demand for alternative amphetamine-like drugs such as the synthetic cathinone, …

Background: Microtubule-targeting agents (MTAs) are a mainstay in breast cancer treatment,
yet patient responses differ. The underlying mechanisms of these differences are unknown. …

Microtubule targeting agents (MTAs) are some of the most effective anticancer drugs used
to treat a wide variety of adult and pediatric cancers. Building evidence suggests that these …

Squamous cell carcinoma (SCC) comprises 90% of all head and neck cancers and has a
poor survival rate due to late-stage disease that is refractive to traditional therapies. Epidermal …

Polygodial, a terpenoid dialdehyde isolated from Polygonum hydropiper L., is a known
agonist of the transient receptor potential vanilloid 1 (TRPV1). In this investigation a series of …

Many types of cancer, including glioma, melanoma, non-small cell lung cancer (NSCLC),
among others, are resistant to proapoptotic stimuli and thus poorly responsive to current …

A series of fourteen N 4 -(substituted phenyl)-N 4 -alkyl/desalkyl-9H-pyrimido[4,5-b]indole-2,4-diamines
was synthesized as potential microtubule targeting agents. The synthesis …

The discovery, synthesis and biological evaluations of a series of nine N5-substituted-pyrrolo[3,2-d]pyrimidin-4-amines
are reported. Novel compounds with microtubule depolymerizing …