Regulation mechanism of ERM (ezrin/radixin/moesin) protein/plasma membrane association: possible involvement of phosphatidylinositol turnover and Rho …

M Hirao, N Sato, T Kondo, S Yonemura… - The Journal of cell …, 1996 - rupress.org
The ERM proteins, ezrin, radixin, and moesin, are involved in the actin filament/plasma
membrane interaction as cross-linkers. CD44 has been identified as one of the major membrane …

Ezrin/radixin/moesin (ERM) proteins bind to a positively charged amino acid cluster in the juxta-membrane cytoplasmic domain of CD44, CD43, and ICAM-2

S Yonemura, M Hirao, Y Doi, N Takahashi… - The Journal of cell …, 1998 - rupress.org
CD44 has been identified as a membrane-binding partner for ezrin/radixin/moesin (ERM)
proteins, plasma membrane/actin filament cross-linkers. ERM proteins, however, are not …

Prevalence of malnutrition among gastric cancer patients undergoing gastrectomy and optimal preoperative nutritional support for preventing surgical site infections

Y Fukuda, K Yamamoto, M Hirao, K Nishikawa… - Annals of surgical …, 2015 - Springer
Background Malnutrition is an independent risk factor for postoperative mortality and morbidity
in major gastrointestinal surgery. The aim of this study was to investigate the prevalence …

[HTML][HTML] Sarcopenia is associated with severe postoperative complications in elderly gastric cancer patients undergoing gastrectomy

Y Fukuda, K Yamamoto, M Hirao, K Nishikawa… - Gastric cancer, 2016 - Springer
Background Malignancy is a secondary cause of sarcopenia, which is associated with
impaired cancer treatment outcomes. The aim of this study was to investigate the prevalence of …

[HTML][HTML] Effectiveness of a preoperative exercise and nutritional support program for elderly sarcopenic patients with gastric cancer

K Yamamoto, Y Nagatsuma, Y Fukuda, M Hirao… - Gastric cancer, 2017 - Springer
We established a preoperative exercise and nutritional support program for elderly sarcopenic
patients with gastric cancer. Twenty-two gastric cancer patients aged 65 years or older …

[HTML][HTML] Alcohol consumption and multiple dysplastic lesions increase risk of squamous cell carcinoma in the esophagus, head, and neck

…, Y Shimizu, H Doyama, T Koike, K Takizawa, M Hirao… - Gastroenterology, 2016 - Elsevier
Background & Aims Some patients develop multiple squamous cell carcinomas (SCCs) in
the upper aerodigestive tract, attributed to field cancerization; alcohol consumption has been …

CC chemokine receptor-7 on dendritic cells is induced after interaction with apoptotic tumor cells: critical role in migration from the tumor site to draining lymph nodes

M Hirao, N Onai, K Hiroishi, SC Watkins, K Matsushima… - Cancer research, 2000 - AACR
Dendritic cells (DCs) are very potent antigen-presenting cells and play critical roles in regulating
immune responses in cancer. The migrating of DCs from the tumor site to the lymphoid …

Induction of systemic and therapeutic antitumor immunity using intratumoral injection of dendritic cells genetically modified to express interleukin 12

Y Nishioka, M Hirao, PD Robbins, MT Lotze, H Tahara - Cancer research, 1999 - AACR
Bone marrow-derived dendritic cells (BM-DCs) retrovirally transduced with genes encoding
murine interleukin (IL)-12 stably expressed bioactive IL-12 protein at high levels. …

[HTML][HTML] Gastrectomy with or without neoadjuvant S-1 plus cisplatin for type 4 or large type 3 gastric cancer (JCOG0501): an open-label, phase 3, randomized …

…, H Katai, T Yoshikawa, S Ito, M Kaji, Y Kimura, M Hirao… - Gastric Cancer, 2021 - Springer
Background Specific treatment strategies are sorely needed for scirrhous-type gastric cancer
still, which has poor prognosis. Based on the promising results of our previous phase II …

Bursectomy versus omentectomy alone for resectable gastric cancer (JCOG1001): a phase 3, open-label, randomised controlled trial

…, N Fukushima, Y Iwasaki, M Kaji, M Hirao… - The Lancet …, 2018 - thelancet.com
Background The role of bursectomy, in which the peritoneal lining covering the pancreas and
the anterior plane of the transverse mesocolon are dissected, has long been controversial …