Aims/hypothesis The newly identified liver- and fat-derived hormone, betatrophin, has
recently been linked to insulin resistance and pancreatic beta cell growth in mice. These …

Gallic acid (GA) is a naturally occurring polyhydroxyphenolic compound and an excellent
free radical scavenger. In this study, we examined its cytotoxic and biochemical effects on the …

Resveratrol (3,4′,5-trihydroxy-trans-stilbene) is a compound found in wine and is held
responsible for a number of beneficial effects of red wine. Besides the prevention of heart …

Background and Aims Sustained virologic response (SVR) to interferon (IFN)‐free therapies
ameliorates portal hypertension (PH); however, it remains unclear whether a decrease in …

Resveratrol is considered to have a number of beneficial effects. Recently, our group modified
the molecule and synthesized a number of compounds with different biochemical effects. …

Ribonucleotide reductase is the rate-limiting enzyme of DNA synthesis, and it has been
shown to be linked with malignant transformation and tumor cell proliferation. It was therefore …

Background: Pancreatic cancer constitutes an entity which is difficult to treat and, therefore,
mostly fatal. Since heavy water (deuterium oxide, D 2 O) was shown to be active in various …

Background: Metal skin clips are used in surgery. They may contain metals that might cause
allergic reactions and delayed wound healing. METHODS: The metal composition of 18 …

Epigallocatechin gallate (EGCG), ellagic acid (EA) and rosmarinic acid (RA) are natural
polyphenols exerting cancer chemopreventive effects. Ribonucleotide reductase (RR; EC 1.17.…

In an aging society, late‐life depression has become an increasing problem. There is evidence
that physical activity ameliorates depressive symptoms and increases the quality of life (…