Recently, the ARID1A gene has been identified as a novel tumor suppressor in ovarian clear
cell carcinoma. The prognostic significance of the loss of ARID1A expression is not known. …

The clinicopathological significance of amplification was investigated of the gene encoding
cyclin E (CCNE1) and we assessed whether CCNE1 was a potential target in endometrioid …

Somatic mutations of PIK3CA (phosphoinositide-3-kinase) have recently been shown playing
an important role in the pathogenesis of ovarian clear cell carcinoma. In this study, the …

BACKGROUND: The goal of this study was to examine the clinical significance of ZNF217
amplification and assess whether ZNF217 could be a potential therapeutic target in ovarian …

Bone metastasis at an advanced disease stage is common in most solid tumors and is
untreatable. Overexpression of receptor activator of nuclear factor κB ligand (RANKL) in tumor-…

This study examined the clinical significance of Notch3 expression and assessed its usefulness
as a potential therapeutic target in chemoresistant ovarian cancer. Notch3 expression …

Somatic mutations in PPP2R1A, which encodes a scaffolding subunit of serine/threonine
protein phosphatase 2A (PP2A), have recently been described in different types of …

Thrombospondin-4 (TSP-4) attracted renewed attention recently as a result of assignment of
new functions to this matricellular protein in cardiovascular, muscular, and nervous systems. …

OBJECTIVE: The aim of this study was to clarify the functional role of Notch3 in human
cervical carcinomas. METHODS: Notch3 expression in cervical cancer was assessed by …

Advanced-stage cancers often metastasize to bone, and is the major cause of cancer-related
morbidity and mortality. Due to poor biodistribution of intravenously administered …