Hedgehog signaling pathway is a new therapeutic target for patients with breast cancer

…, H Nakashima, M Nomura, S Kuroki, M Katano - Cancer research, 2004 - AACR
The Hedgehog (Hh) signaling pathway functions as an organizer in embryonic development.
Genetic analysis has demonstrated a critical role for the Hh pathway in mammary gland …

Nuclear factor-κB p65 (RelA) transcription factor is constitutively activated in human gastric carcinoma tissue

…, T Yamanaka, A Uchiyama, M Tanaka, M Katano - Clinical Cancer …, 2001 - AACR
Purpose: Activation of transcription factor nuclear factor-κB (NF-κB) has been shown to play
a role in cell proliferation, apoptosis, cytokine production, and oncogenesis. The purpose of …

Purification, characterization and biological significance of tumor-derived exosomes

…, M Nakamura, S Kuroki, M Tanaka, M Katano - Anticancer …, 2005 - ar.iiarjournals.org
Exosomes are nanovesicles that are released into the extracellular environment during the
fusion of multivesicular bodies with the plasma membrane. Exosomes released from …

Cytotoxic activity of polyacetylene compounds in Panax ginseng CA Meyer

H MATSUNAGA, M Katano, H Yamamoto… - Chemical and …, 1990 - jstage.jst.go.jp
The effects of the three polyacetylene compounds, panaxynol, panaxydol and panaxytriol,
on in vitro-cell growth were studied. these compounds are much different in their water-…

Increased nuclear factor-kB activation in human colorectal carcinoma and its correlation with tumor progression

…, K Nakano, R Mibu, M Tanaka, M Katano - Anticancer …, 2004 - ar.iiarjournals.org
Objectives: Nuclear factor-kB (NF-kB) is a transcription factor that participates in the induction
of several genes for cytokines and enzymes that play important functional roles in various …

Nuclear factor-κB contributes to hedgehog signaling pathway activation through sonic hedgehog induction in pancreatic cancer

…, K Yamaguchi, M Tsuneyoshi, M Tanaka, M Katano - Cancer research, 2006 - AACR
The hedgehog (Hh) signaling pathway, which functions as an organizer in embryonic
development, is implicated in the development of various tumors. In pancreatic cancer, pathway …

Intratumoral CD8+ T/FOXP3+ cell ratio is a predictive marker for survival in patients with colorectal cancer

…, M Tanaka, H Onishi, T Morisaki, M Katano - Cancer immunology …, 2010 - Springer
The human immune system consists of a balance between immune surveillance against non-self
antigens and tolerance of self-antigens. CD8 + T cells and CD4 + regulatory T cells (…

Antiproliferative constituents from umbelliferae plants. V. A new furanocoumarin and falcarindiol furanocoumarin ethers from the root of Angelica japonica

…, Y Nakano, H Matsunaga, M Katano… - Chemical and …, 1999 - jstage.jst.go.jp
The CHCl 3 extract of the root of Angelica japonica showed high inhibitory activity against
human gastric adenocarcinoma (MK-1) cell growth. From this extract, a new furanocoumarin …

Lipopolysaccharide (LPS) increases the invasive ability of pancreatic cancer cells through the TLR4/MyD88 signaling pathway

…, M Kubo, M Tanaka, H Onishi, M Katano - Journal of surgical …, 2009 - Wiley Online Library
Background Inflammation plays a multifaceted role in cancer progression, and NF‐κB is one
of the key factors connecting inflammation with cancer progression. We have shown that …

The contribution of vascular endothelial growth factor to the induction of regulatory T-cells in malignant effusions

…, M Tanaka, T Morisaki, M Katano - Anticancer …, 2009 - ar.iiarjournals.org
It has been suggested that immunosuppressive cytokines such as transforming growth factor
β (TGF-β) and interleukin 10 play an important role in the induction and/or maintenance of …