User profiles for MINORU KOI

Minoru Koi

University of Michigan
Verified email at med.umich.edu
Cited by 7273

The biochemical basis of microsatellite instability and abnormal immunohistochemistry and clinical behavior in Lynch syndrome: from bench to bedside

CR Boland, M Koi, DK Chang, JM Carethers - Familial cancer, 2008 - Springer
Lynch syndrome is an inherited disease caused by a germline mutation in one of four DNA
mismatch repair (MMR) genes. The clinical manifestations can be somewhat variable …

The colorectal cancer immune microenvironment and approach to immunotherapies

M Koi, JM Carethers - Future Oncology, 2017 - Future Medicine
Colorectal cancer (CRC) is the third most common cancer in the world, with about 1.4
million cases diagnosed worldwide in 2012 [1]. The prognosis for CRC patients is largely …

[HTML][HTML] EMAST is a form of microsatellite instability that is initiated by inflammation and modulates colorectal cancer progression

JM Carethers, M Koi, SS Tseng-Rogenski - Genes, 2015 - mdpi.com
DNA mismatch repair (MMR) function is critical for correcting errors coincident with
polymerase-driven DNA replication, and its proteins are frequent targets for inactivation (germline or …

Loss of DNA mismatch repair in acquired resistance to cisplatin

…, H Zheng, D Fink, RD Christen, CR Boland, M Koi… - Cancer research, 1996 - AACR
Selection of cells for resistance to cisplatin, a well-recognized mutagen, could result in
mutations in genes involved in DNA mismatch repair and thereby to resistance to DNA-alkylating …

MicroRNA-200c modulates epithelial-to-mesenchymal transition (EMT) in human colorectal cancer metastasis

…, F Balaguer, T Nagasaka, J Koike, H Hemmi, M Koi… - Gut, 2013 - gut.bmj.com
Objective Distant metastasis is the major cause of cancer-related death in patients with
colorectal cancer (CRC). Although the microRNA-200 (miR-200) family is a crucial inhibitor of …

Human Chromosome 3 Corrects Mismatch Repair Deficiency and Microsatellite Instability and Reduces N-Methyl-N′-nitro-N-nitrosoguanidine Tolerance in Colon Tumor …

M Koi, A Umar, DP Chauhan, SP Cherian… - Cancer research, 1994 - AACR
The human colon tumor cell line HCT 116 is known to have a homozygous mutation in the
mismatch repair gene hMLH1 on human chromosome 3, to exhibit microsatellite instability, …

Evidence for a Connection between the Mismatch Repair System and the G2 Cell Cycle Checkpoint

…, JM Carethers, G Marra, TA Kunkel, CR Boland, M Koi - Cancer Research, 1995 - AACR
The human colon tumor cell line HCT116 is deficient in wild-type hMLH1, is defective in
mismatch repair (MMR), exhibits microsatellite instability, and is tolerant to N-methyl-N′-nitro-N-…

Transcription-coupled repair deficiency and mutations in human mismatch repair genes

I Mellon, DK Rajpal, M Koi, CR Boland, GN Champe - Science, 1996 - science.org
Deficiencies in mismatch repair have been linked to a common cancer predisposition
syndrome in humans, hereditary nonpolyposis colorectal cancer (HNPCC), and a subset of …

Genetic instability caused by loss of MutS homologue 3 in human colorectal cancer

…, K Shibuya, M Oshimura, H Hemmi, CR Boland, M Koi - Cancer research, 2008 - AACR
Microsatellite instability (MSI) is a hallmark of mismatch repair (MMR) deficiency. High
levels of MSI at mononucleotide and dinucleotide repeats in colorectal cancer (CRC) are …

Analysis of fecal DNA methylation to detect gastrointestinal neoplasia

…, DS Sun, H Sasamoto, T Uchida, M Koi… - JNCI: Journal of the …, 2009 - academic.oup.com
Background The development of noninvasive screening tests is important to reduce mortality
from gastrointestinal neoplasia. We sought to develop such a test by analysis of DNA …