User profiles for MINORU KOI
Minoru KoiUniversity of Michigan Verified email at med.umich.edu Cited by 7273 |
The biochemical basis of microsatellite instability and abnormal immunohistochemistry and clinical behavior in Lynch syndrome: from bench to bedside
Lynch syndrome is an inherited disease caused by a germline mutation in one of four DNA
mismatch repair (MMR) genes. The clinical manifestations can be somewhat variable …
mismatch repair (MMR) genes. The clinical manifestations can be somewhat variable …
The colorectal cancer immune microenvironment and approach to immunotherapies
M Koi, JM Carethers - Future Oncology, 2017 - Future Medicine
Colorectal cancer (CRC) is the third most common cancer in the world, with about 1.4
million cases diagnosed worldwide in 2012 [1]. The prognosis for CRC patients is largely …
million cases diagnosed worldwide in 2012 [1]. The prognosis for CRC patients is largely …
[HTML][HTML] EMAST is a form of microsatellite instability that is initiated by inflammation and modulates colorectal cancer progression
JM Carethers, M Koi, SS Tseng-Rogenski - Genes, 2015 - mdpi.com
DNA mismatch repair (MMR) function is critical for correcting errors coincident with
polymerase-driven DNA replication, and its proteins are frequent targets for inactivation (germline or …
polymerase-driven DNA replication, and its proteins are frequent targets for inactivation (germline or …
Loss of DNA mismatch repair in acquired resistance to cisplatin
Selection of cells for resistance to cisplatin, a well-recognized mutagen, could result in
mutations in genes involved in DNA mismatch repair and thereby to resistance to DNA-alkylating …
mutations in genes involved in DNA mismatch repair and thereby to resistance to DNA-alkylating …
MicroRNA-200c modulates epithelial-to-mesenchymal transition (EMT) in human colorectal cancer metastasis
Objective Distant metastasis is the major cause of cancer-related death in patients with
colorectal cancer (CRC). Although the microRNA-200 (miR-200) family is a crucial inhibitor of …
colorectal cancer (CRC). Although the microRNA-200 (miR-200) family is a crucial inhibitor of …
Human Chromosome 3 Corrects Mismatch Repair Deficiency and Microsatellite Instability and Reduces N-Methyl-N′-nitro-N-nitrosoguanidine Tolerance in Colon Tumor …
The human colon tumor cell line HCT 116 is known to have a homozygous mutation in the
mismatch repair gene hMLH1 on human chromosome 3, to exhibit microsatellite instability, …
mismatch repair gene hMLH1 on human chromosome 3, to exhibit microsatellite instability, …
Evidence for a Connection between the Mismatch Repair System and the G2 Cell Cycle Checkpoint
The human colon tumor cell line HCT116 is deficient in wild-type hMLH1, is defective in
mismatch repair (MMR), exhibits microsatellite instability, and is tolerant to N-methyl-N′-nitro-N-…
mismatch repair (MMR), exhibits microsatellite instability, and is tolerant to N-methyl-N′-nitro-N-…
Transcription-coupled repair deficiency and mutations in human mismatch repair genes
Deficiencies in mismatch repair have been linked to a common cancer predisposition
syndrome in humans, hereditary nonpolyposis colorectal cancer (HNPCC), and a subset of …
syndrome in humans, hereditary nonpolyposis colorectal cancer (HNPCC), and a subset of …
Genetic instability caused by loss of MutS homologue 3 in human colorectal cancer
Microsatellite instability (MSI) is a hallmark of mismatch repair (MMR) deficiency. High
levels of MSI at mononucleotide and dinucleotide repeats in colorectal cancer (CRC) are …
levels of MSI at mononucleotide and dinucleotide repeats in colorectal cancer (CRC) are …
Analysis of fecal DNA methylation to detect gastrointestinal neoplasia
…, DS Sun, H Sasamoto, T Uchida, M Koi… - JNCI: Journal of the …, 2009 - academic.oup.com
Background The development of noninvasive screening tests is important to reduce mortality
from gastrointestinal neoplasia. We sought to develop such a test by analysis of DNA …
from gastrointestinal neoplasia. We sought to develop such a test by analysis of DNA …