In an open, randomized four-period crossover study in 24 healthy male volunteers a newly
developed tramadol (CAS 27203-92-5) sustained release capsule with and without …

Background and purpose Motivated by first animal trials showing the normal tissue protecting
effect of electron and photon Flash irradiation, ie at mean dose rates of 100 Gy/s and higher…

The bioavailability of β-aescin—the main active constituent of horse chestnut seed extract—in
a nonretarded test medication in comparison with that in a retarded reference formulation …

Background and purpose Continuing recent experiments at the research electron accelerator
ELBE at the Helmholtz-Zentrum Dresden-Rossendorf the influence of beam pulse structure …

The objective of these two open phase I clinical trials was the investigation of the bioavailability
of five constituents from a hypericum extract containing tablet, which are discussed as …

Background and purpose In consequence of a previous study, where no protecting proton
Flash effect was found for zebrafish embryos, potential reasons and requirements for inducing …

Hypericins, hyperforin and flavonoids are discussed as the main components contributing to
the antidepressant action of St. John’s wort (Hypericum perforatum). Therefore, the …

The long-term goal to integrate laser-based particle accelerators into radiotherapy clinics
not only requires technological development of high-intensity lasers and new techniques for …

The recently observed FLASH effect describes the observation of normal tissue protection
by ultra-high dose rates (UHDR), or dose delivery in a fraction of a second, at similar tumor-…

Purpose: In order to take full advantage of proton radiotherapy, the biological effect of protons
in normal and tumor tissue should be investigated and understood in detail. The ongoing …