User profiles for MICHAEL A. GROTZER

Michael Grotzer

Professor of Pediatrics, University Children's Hospital of Zurich
Verified email at kispi.uzh.ch
Cited by 13112

Resistance to tumor necrosis factor-related apoptosis-inducing ligand-induced apoptosis in neuroblastoma cells correlates with a loss of caspase-8 expression

A Eggert, MA Grotzer, TJ Zuzak, BR Wiewrodt, R Ho… - Cancer research, 2001 - AACR
Disruption of apoptotic pathways may be involved in tumor formation,regression, and
treatment resistance of neuroblastoma (NB). Tumor necrosis factor-related apoptosis-inducing …

Outcome of craniopharyngioma in children: long-term complications and quality of life

A Poretti, MA Grotzer, K Ribi, E Schönle… - … medicine and child …, 2004 - cambridge.org
Childhood craniopharyngiomas are histologically benign tumours arising from remnants of
Rathke's pouch in the hypothalamic–pituitary region. The two common treatment approaches …

[HTML][HTML] Clinical, radiologic, pathologic, and molecular characteristics of long-term survivors of diffuse intrinsic pontine glioma (DIPG): a collaborative report from the …

…, SM Pfister, NU Gerber, MA Grotzer… - Journal of clinical …, 2018 - ncbi.nlm.nih.gov
Purpose Diffuse intrinsic pontine glioma (DIPG) is a brainstem malignancy with a median
survival of< 1 year. The International and European Society for Pediatric Oncology DIPG …

[HTML][HTML] Alterations in ALK/ROS1/NTRK/MET drive a group of infantile hemispheric gliomas

…, M Perez-Somarriba, CC Faria, MA Grotzer… - Nature …, 2019 - nature.com
Infant gliomas have paradoxical clinical behavior compared to those in children and adults:
low-grade tumors have a higher mortality rate, while high-grade tumors have a better …

Delay in the diagnosis of paediatric brain tumours

…, H Hengartner, E Boltshauser, MA Grotzer - European journal of …, 2002 - Springer
The pre-diagnostic period of 252 children (median age 6.3 years, range 0–16.9 years) with
primary brain tumours was assessed to analyse their clinical presentation and reasons for …

[HTML][HTML] Alterations in ALK/ROS1/NTRK/MET drive a group of infantile hemispheric gliomas

…, M Perez-Somarriba, CC Faria, MA Grotzer… - Nature …, 2019 - ncbi.nlm.nih.gov
Infant gliomas have paradoxical clinical behavior compared to those in children and adults:
low-grade tumors have a higher mortality rate, while high-grade tumors have a better …

Background ionizing radiation and the risk of childhood cancer: a census-based nationwide cohort study

…, M Röösli, F Niggli, MA Grotzer… - Environmental …, 2015 - ehp.niehs.nih.gov
Background Exposure to medium or high doses of ionizing radiation is a known risk factor for
cancer in children. The extent to which low-dose radiation from natural sources contributes …

[HTML][HTML] Resistance to TRAIL-induced apoptosis in primitive neuroectodermal brain tumor cells correlates with a loss of caspase-8 expression

MA Grotzer, A Eggert, TJ Zuzak, AJ Janss, S Marwaha… - Oncogene, 2000 - nature.com
TNF-related apoptosis-inducing ligand (TRAIL) is a potent inducer of apoptosis in adult
malignant glioma and various other human solid tumor models but not in normal tissues. To …

MYC Messenger RNA Expression Predicts Survival Outcome in Childhood Primitive Neuroectodermal Tumor/Medulloblastoma

MA Grotzer, MD Hogarty, AJ Janss, X Liu, H Zhao… - Clinical cancer …, 2001 - AACR
Purpose and Experimental Design: Cerebellar primitive neuroectodermal tumors/medulloblastomas
(PNET/MB) are the most common malignant brain tumors in childhood. To identify …

Imipridones affect tumor bioenergetics and promote cell lineage differentiation in diffuse midline gliomas

…, MD Dun, C Koschmann, JE Cain, MA Grotzer… - Neuro …, 2022 - academic.oup.com
Background Pediatric diffuse midline gliomas (DMGs) are incurable childhood cancers. The
imipridone ONC201 has shown early clinical efficacy in a subset of DMGs. However, the …