Glycogen synthase kinase 3β (GSK3β) reportedly has opposing roles, repressing Wnt/β-catenin
signaling on the one hand but maintaining cell survival and proliferation through the NF-…

Angiogenesis is essential for tumor growth and metastasis and depends on the production
of angiogenic factors by host and/or tumor cells. The role of angiogenesis and angiogenic …

Background. Many studies on postoperative carcinoembryonic antigen (CEA) and/or
carbohydrate antigen (CA)19-9 monitoring after operation for gastric cancer have been reported, …

We have examined the implications of membrane-type matrix metalloproteinase (MT-MMP)
for activation of the zymogen of MMP-2 (proMMP-2) in human gastric carcinoma. Northern …

We examined the production and tissue localization of matrix metalloproteinases (MMPs)
and tissue inhibitors of metalloproteinases (TIMPs) in gastric carcinoma tissues. MMP‐I (tissue …

Gene amplifications of c-myc, K-sam, and c-met were examined in cancer nuclei isolated
from 154 primary gastric adenocarcinomas by fluorescence in situ hybridization (FISH) using …

Background: The ubiquitin–proteasome pathway is important in regulating protein signaling
pathways that are involved in tumorigenesis. β-transducin repeat–containing proteins (β-…

Multiple genomic alterations are involved in the development of most human cancers. They
include alterations in oncogenes, tumor suppressor genes, DNA mismatch repair and …

Uncontrolled expression of matrix metalloproteinases 2, 3 and 9 (MMP-2,-3 and-9) is
believed to be a critical part of the invasive potential of tumor cells because of their ability to …

This review highlights current knowledge of environmental factors in carcinogenesis and
their cellular targets. The hypothesis that environmental factors influence carcinogenesis is …