Background A large number of patients suffer recurrence after curative resection, and mortality
from colon cancer remains high. The role of systemic inflammatory response, as reflected …

Background This study compared the efficacy of regorafenib and trifluridine/tipiracil (TFTD)
in patients with metastatic colorectal cancer (mCRC) who are refractory to standard …

AIM: To investigate how complete laparoscopic anterior resection with natural orifice
specimen extraction (NOSE), as a novel minimally invasive surgery, compares to conventional …

Colorectal cancer (CRC) is one of the most daunting diseases due to its increasing
worldwide prevalence, which requires imperative development of minimally or non-invasive …

Polyamine metabolites provide pathophysiological information on disease or therapeutic
efficacy, yet rapid screening methods for these biomarkers are lacking. Here, we developed …

Colorectal cancer (CRC) has increasing global prevalence and poor prognostic outcomes,
and the development of low- or less invasive screening tests is urgently required. Urine is an …

Vitamin K2 (VK2) has a growth inhibitory effect on various types of cancer cells in vitro, and
its efficacy has been demonstrated in clinical applications in a number of patients with …

As the worldwide prevalence of colorectal cancer (CRC) increases, it is vital to reduce its
morbidity and mortality through early detection. Saliva‐based tests are an ideal noninvasive …

Aim: Anastomotic leakage (AL) in left-sided colorectal cancer is a serious complication, with
an incidence rate of 6-18%. We developed a novel predictive model for AL in colorectal …

Background Lateral pelvic lymph node (LPLN) dissection is becoming increasingly important
in the treatment of advanced low rectal cancer patients. However, the surgery has several …