The immunological mechanisms required to engender resistance have been defined in few
infectious diseases of man, and the role of specific cytokines is unclear. Leprosy presents …

As a psoriatic lesion develops at sites of previously uninvolved skin, cytokines and their
subsequent induction of various adhesion molecules may play important pathophysiologic roles. …

Objective CD14+,CD16+ monocytes, identified as a minor population of monocytes in
human peripheral blood (PB), have been implicated in several inflammatory diseases. We …

S100A8 and S100A9, two Ca 2+ -binding proteins of the S100 family, are secreted as a
heterodimeric complex (S100A8/A9) from neutrophils and monocytes/macrophages. Serum and …

Objective To examine whether depsipeptide (FK228), a histone deacetylase (HDA) inhibitor,
has inhibitory effects on the proliferation of synovial fibroblasts from rheumatoid arthritis (RA…

Objective CD16 (IgG Fcγ receptor type IIIA [FcγRIIIA])–expressing CD14+ monocytes
express high levels of Toll‐like receptor 2 (TLR‐2) and are able to efficiently produce …

Reactional states in leprosy are produced by different immunologic mechanisms and are
responsible for a major component of tissue damage of the disease. Reversal reactions exhibit …

Objective. Interleukin-18 (IL-18) is a proinflam-matory cytokine that is involved in immunologically
mediated tissue damage, but its bioactivity is regulated in vivo by its soluble decoy …

Objective. To determine the expression of interleukin‐6 (IL‐6), IL‐11, leukemia inhibitory factor
(LIF), and oncostatin M (OSM) and their major cellular sources in the joints of rheumatoid …

IL-10 and IL-4 have been shown to exert an inhibitory effect on cell-mediated immune
responses. Our previous studies of leprosy demonstrated that IL-10 and IL-4 mRNA were …