Interleukin‐13 receptor α2 chain: A potential biomarker and molecular target for ovarian cancer therapy

M Kioi, M Kawakami, T Shimamura, SR Husain… - Cancer, 2006 - Wiley Online Library
BACKGROUND Epithelial ovarian cancer demonstrates high mortality due to diagnosis at
an advanced stage. In the search for a biomarker for early diagnosis and a target for therapy, …

Analysis of interleukin‐13 receptor α2 expression in human pediatric brain tumors

M Kawakami, K Kawakami, S Takahashi, M Abe… - Cancer, 2004 - Wiley Online Library
BACKGROUND Compared with normal brain tissue cells, human malignant glioma cells
express higher levels of interleukin‐13 receptor (IL‐13R). However, whether this receptor is …

Anti-tumor effects of bevacizumab in combination with paclitaxel on head and neck squamous cell carcinoma

…, M Kimura, Y Yamashita, M Kawakami… - Oncology …, 2007 - spandidos-publications.com
Human tumors are dependent on angiogenesis for growth, and the vascular endothelial
growth factor (VEGF) is a major regulator of this process. Bevacizumab (Avastin®), a …

Interleukin-4-Pseudomonas Exotoxin Chimeric Fusion Protein for Malignant Glioma Therapy

M Kawakami, K Kawakami, RK Puri - Journal of neuro-oncology, 2003 - Springer
Human malignant glioma cell lines, primary cell cultures, and tumor specimens derived from
surgical samples have been shown to overexpress high-affinity receptors (R) for interleukin-…

Distribution kinetics of targeted cytotoxin in glioma by bolus or convection-enhanced delivery in a murine model

K Kawakami, M Kawakami, M Kioi, SR Husain… - Journal of …, 2004 - thejns.org
Object. Interleukin-13 receptor (IL-13R)—targeted cytotoxin (IL-13—PE38) displays a potent
antitumor activity against a variety of human tumors including glioblastoma multiforme (GBM…

Interleukin-13 receptor α2 chain in human head and neck cancer serves as a unique diagnostic marker

M Kawakami, K Kawakami, JL Kasperbauer… - Clinical cancer …, 2003 - AACR
Previous studies have demonstrated that approximately 30% of squamous cell carcinoma of
the head and neck (SCCHN) cell lines express high levels of interleukin-13 receptor(s) (IL-…

Interleukin 4 receptor on human lung cancer: a molecular target for cytotoxin therapy

M Kawakami, K Kawakami, VA Stepensky, RA Maki… - Clinical cancer …, 2002 - AACR
Previous studies have demonstrated that human lung tumor cell lines express interleukin 4 (IL-4)
receptors, and IL-4 can mediate modest to moderate antiproliferative activity in vitro …

In vivo overexpression of IL-13 receptor α2 chain inhibits tumorigenicity of human breast and pancreatic tumors in immunodeficient mice

K Kawakami, M Kawakami, PJ Snoy… - The Journal of …, 2001 - rupress.org
Interleukin 13 receptor α2 (IL-13Rα2) chain is highly expressed on some tumor cell lines
and primary cell cultures. This receptor chain plays an important role in ligand binding and …

Interleukin-13 receptor-targeted cancer therapy in an immunodeficient animal model of human head and neck cancer

K Kawakami, M Kawakami, BH Joshi, RK Puri - Cancer research, 2001 - AACR
Although interleukin-13 receptors (IL-13R) are overexpressed on several head and neck
cancer cell lines, a majority of cell lines express only low levels of IL-13R. We have found that …

Targeting interleukin-4 receptors for effective pancreatic cancer therapy

K Kawakami, M Kawakami, SR Husain, RK Puri - Cancer research, 2002 - AACR
We demonstrate that pancreatic cancer tissues express receptors for interleukin (IL)-4 in situ
at highdensity. Using the approach of selective receptor targeting, we have tested the …