Tumour microenvironment determines the fate of treatments. Reconstitution of tumour
conditions is mandatory for alternative in vitro methods devoted to cancer development and the …

Multidrug resistance (MDR) of cancer cells constitutes one of the main reasons for
chemotherapy failure. The search for nontoxic modulators that reduce MDR is a task of great …

Cyclophosphamide (CP) is an anti-tumor drug commonly used in the chemotherapy of human
cancer and autoimmune diseases. In our previous studies, we have demonstrated that …

Endothelial progenitor cells (EPCs) and mesenchymal stem/stromal cells (MSCs) are associated
with maintaining tissue homeostasis and tissue repair. Both types of cells contribute to …

Background Mesenchymal stem cells (MSCs) secrete a cocktail of growth factors and
cytokines, which could promote tissue regeneration and wound healing. Therefore, in clinical …

Endothelial progenitor cells (EPCs) modulate postnatal vascularization and contribute to vessel
regeneration in adults. Stem cells and progenitor cells were found in umbilical cord blood…

Flavonoids with hydrophobic eg prenyl substituents might constitute the promising candidates
for multidrug resistance (MDR) reversal agents. The interaction of 8-prenylnaringenin (8-…

The choice of cell lines for multidrug resistance (MDR) modulators screening may affect the
results obtained. Screening is most often performed in model systems which employ cell …

Maternal endothelial dysfunction is one of the main features of pregnancy-induced hypertension
(PIH). It is generally accepted that circulating endothelial cells (CECs) and endothelial …

Metallacarboranes are anionic boron clusters with high affinity to serum albumin, ability to
cross biological membranes, and no apparent toxicity in vitro and in vivo. Thus, conjugation …