Repeated, local, nonviral IL12 (interleukin-12) gene delivery decreased tumor progression
and increased immunogenicity. We combined our IL12 gene delivery with systemic paclitaxel …

Biodegradable cationic polymers have become promising alternatives to traditional
polycationic gene delivery systems in which the high charge densities of high molecular weight …

Inactivation of p53 pathway is reported in more than half of all human tumors and can be
correlated to malignant development. Missense mutation in the DNA binding region of p53 is …

Development of improved gene transfer methods is needed for gene therapy to achieve its
clinical potential. The use of biocompatible polymeric gene carriers has shown effectiveness …

This project uses an ex vivo human perfusion model for studying transport in benign, fibrous
tumors. The uterine arteries were cannulated to perfuse the organ with a buffer solution …

Objectives AL3818 (anlotinib) is a receptor tyrosine kinase inhibitor targeting vascular
endothelial growth factor receptors (VEGFR1, VEGFR2/KDR, and VEGFR3), stem cell factor …

… Coombs, Paul Chen, Margit M. Janát-Amsbury. Treatment of endometrial cancer cells with
a new small tyrosine kinase inhibitor targeting mutated fibroblast growth factor receptor-2 […

Attempts to develop novel immunotherapeutic mouse models have been hampered by the
lack of an adequate in vivo system. This study was performed to establish an …

Objective: AL3818 (Anlotinib) is a receptor tyrosine kinase inhibitor targeting vascular
endothelial growth factor receptors (VEGFR1, VEGFR2/KDR, and VEGFR3), stem cell factor …

The in vivo feasibility of the previously established ID8 and ID8-VEGF ovarian cancer models
for non-viral IL-12 gene delivery by itself or in combination with paclitaxel chemotherapy, …