Altered expression of miR-21, miR-31, miR-143 and miR-145 is related to clinicopathologic features of colorectal cancer

O Slaby, M Svoboda, P Fabian, T Smerdova… - Oncology, 2008 - karger.com
Objectives: Development and metastases of colorectal cancer (CRC) are characterized by
multiple genetic alterations. MicroRNAs (miRNAs) are endogenously expressed regulatory …

[HTML][HTML] MicroRNAs in colorectal cancer: translation of molecular biology into clinical application

O Slaby, M Svoboda, J Michalek, R Vyzula - Molecular cancer, 2009 - Springer
MicroRNAs (miRNAs) are small non-coding RNAs 18-25 nucleotides in length that
downregulate gene expression during various crucial cell processes such as apoptosis, …

[HTML][HTML] Novel classes of non-coding RNAs and cancer

J Sana, P Faltejskova, M Svoboda, O Slaby - Journal of translational …, 2012 - Springer
For the many years, the central dogma of molecular biology has been that RNA functions
mainly as an informational intermediate between a DNA sequence and its encoded protein. But …

[HTML][HTML] Circulating miR-378 and miR-451 in serum are potential biomarkers for renal cell carcinoma

…, R Iliev, L Radova, R Lakomy, M Svoboda… - Journal of translational …, 2012 - Springer
Background There is no standard serum biomarker used for diagnosis or early detection of
recurrence for renal cell carcinoma (RCC) patients. MicroRNAs (miRNAs) are abundant and …

MiR‐195, miR‐196b, miR‐181c, miR‐21 expression levels and O‐6‐methylguanine‐DNA methyltransferase methylation status are associated with clinical outcome …

…, P Fadrus, L Kren, E Lzicarova, M Svoboda… - Cancer …, 2011 - Wiley Online Library
Glioblastoma multiforme (GBM) is the most frequently occurring primary malignant brain tumor;
patients with GBM often have a very poor prognosis and differing responses to treatment. …

[HTML][HTML] Long non-coding RNA ZFAS1 interacts with CDK1 and is involved in p53-dependent cell cycle control and apoptosis in colorectal cancer

…, S Hombach, J Mlcochova, M Kretz, M Svoboda… - Oncotarget, 2016 - ncbi.nlm.nih.gov
We determined expression of 83 long non-coding RNAs (lncRNAs) and identified ZFAS1 to
be significantly up-regulated in colorectal cancer (CRC) tissue. In cohort of 119 CRC patients …

Genetic polymorphisms and microRNAs: new direction in molecular epidemiology of solid cancer

…, J Bienertova‐Vasku, M Svoboda… - Journal of cellular …, 2012 - Wiley Online Library
Marek SvobodaMarek SvobodaMarek Svoboda

Identification and functional screening of micro RNA s highly deregulated in colorectal cancer

P Faltejskova, M Svoboda, K Srutova… - Journal of cellular …, 2012 - Wiley Online Library
Micro RNA s (mi RNA s) constitute a robust regulatory network with post‐transcriptional
regulatory efficiency for almost one half of human coding genes, including oncogenes and …

[PDF][PDF] MicroRNA-181 family predicts response to concomitant chemoradiotherapy with temozolomide in glioblastoma patients

…, R Hrstka, L Kren, E Lzicarova, M Smrcka, M Svoboda… - Neoplasma, 2010 - is.muni.cz
MicroRNAs are endogenously expressed regulatory noncoding RNAs. Previous studies
showed altered expression levels of several microRNAs in glioblastomas. In this study, we …

[HTML][HTML] MicroRNA expression profile associated with response to neoadjuvant chemoradiotherapy in locally advanced rectal cancer patients

M Svoboda, J Sana, P Fabian, I Kocakova… - Radiation …, 2012 - Springer
Background Rectal cancer accounts for approximately one third of all colorectal cancers (CRC),
which belong among leading causes of cancer deaths worldwide. Standard treatment …