Diruthenium (II, III) complexes of ibuprofen, aspirin, naproxen and indomethacin non-steroidal anti-inflammatory drugs: Synthesis, characterization and their effects on …
G Ribeiro, M Benadiba, A Colquhoun… - Polyhedron, 2008 - Elsevier
[Ru 2 (dNSAID) 4 Cl] and novel [Ru 2 (dNSAID) 4 (H 2 O) 2 ]PF 6 complexes, where dNSAID=deprotonated
carboxylate from the non-steroidal anti-inflammatory drugs (NSAIDs), …
carboxylate from the non-steroidal anti-inflammatory drugs (NSAIDs), …
[HTML][HTML] Gamma-linolenic acid inhibits both tumour cell cycle progression and angiogenesis in the orthotopic C6 glioma model through changes in VEGF, Flt1, ERK1/2 …
JA Miyake, M Benadiba, A Colquhoun - Lipids in Health and Disease, 2009 - Springer
Background Gamma-linolenic acid is a known inhibitor of tumour cell proliferation and migration
in both in vitro and in vivo conditions. The aim of the present study was to determine the …
in both in vitro and in vivo conditions. The aim of the present study was to determine the …
Inhibition of C6 rat glioma proliferation by [Ru2Cl (Ibp) 4] depends on changes in p21, p27, Bax/Bcl2 ratio and mitochondrial membrane potential
M Benadiba, RRP Dos Santos… - Journal of inorganic …, 2010 - Elsevier
The ruthenium compound [Ru 2 Cl(Ibp) 4 ] (or RuIbp) has been reported to cause significantly
greater inhibition of C6 glioma cell proliferation than the parent HIbp. The present study …
greater inhibition of C6 glioma cell proliferation than the parent HIbp. The present study …
[HTML][HTML] New molecular targets for PET and SPECT imaging in neurodegenerative diseases
M Benadiba, G Luurtsema, L Wichert-Ana… - Brazilian Journal of …, 2012 - SciELO Brasil
The pathophysiology of neurodegenerative diseases (ND) such as Alzheimer's disease (AD)
and Parkinson's disease (PD) has not yet been completely elucidated. However, in the past …
and Parkinson's disease (PD) has not yet been completely elucidated. However, in the past …
Growth inhibitory effects of the Diruthenium-Ibuprofen compound, [Ru2Cl(Ibp)4], in human glioma cells in vitro and in the rat C6 orthotopic glioma in vivo
M Benadiba, I de M. Costa, RLSR Santos… - JBIC Journal of …, 2014 - Springer
The Diruthenium-Ibuprofen compound [Ru 2 Cl(Ibp) 4 ] (or RuIbp) is known to cause significant
inhibition of C6 rat glioma cell proliferation in vitro. RuIbp increased the expression of cell …
inhibition of C6 rat glioma cell proliferation in vitro. RuIbp increased the expression of cell …
The novel ruthenium—γ‐linolenic complex [Ru2(aGLA)4Cl] inhibits C6 rat glioma cell proliferation and induces changes in mitochondrial membrane potential, increased …
G Ribeiro, M Benadiba… - … biochemistry and its …, 2010 - Wiley Online Library
The present study reports the synthesis of a novel compound with the formula [Ru 2 (aGLA)4Cl]
according to elemental analyses data, referred to as Ru 2 GLA. The electronic spectra of …
according to elemental analyses data, referred to as Ru 2 GLA. The electronic spectra of …
Novel ruthenium–gamma-linolenic acid complex inhibits C6 rat glioma cell proliferation in vitro and in the orthotopic C6 model in vivo after osmotic pump infusion
Aim: Gliomas are primary brain tumours. Gamma-linolenic acid (GLA) exerts anti-proliferative
effects. Several ruthenium-containing complexes have antiproliferative effects and can be …
effects. Several ruthenium-containing complexes have antiproliferative effects and can be …
Importance of ABC transporters in drug development
M Benadiba, Y Maor - Current pharmaceutical design, 2016 - ingentaconnect.com
ATP-binding cassette (ABC) transporters are a huge family of ATP-dependent transmembrane
proteins whose main function is exporting or importing substances or molecules through …
proteins whose main function is exporting or importing substances or molecules through …
Gamma‐linolenic acid alters Ku80, E2F1, and bax expression and induces micronucleus formation in C6 glioma cells in vitro
M Benadiba, JA Miyake, A Colquhoun - IUBMB life, 2009 - Wiley Online Library
Gamma‐linolenic acid (GLA) is an inhibitor of tumor cell proliferation in both in vitro and in
vivo conditions. The aim of this study was to investigate the effects of 150 μM GLA on the …
vivo conditions. The aim of this study was to investigate the effects of 150 μM GLA on the …
11C‐ and 18F‐Labeled Radioligands for P‐Glycoprotein Imaging by Positron Emission Tomography
M Cantore, M Benadiba, PH Elsinga… - …, 2016 - Wiley Online Library
P‐Glycoprotein (P‐gp) is an efflux transporter widely expressed at the human blood–brain
barrier. It is involved in xenobiotics efflux and in onset and progression of neurodegenerative …
barrier. It is involved in xenobiotics efflux and in onset and progression of neurodegenerative …