Glypican‐3 expression is correlated with poor prognosis in hepatocellular carcinoma

H Shirakawa, H Suzuki, M Shimomura… - Cancer …, 2009 - Wiley Online Library
The relationship between overexpression of glypican (GPC)‐3 that is specific for
hepatocellular carcinoma (HCC) and the prognosis has not yet been clarified. We attempted to …

[HTML][HTML] Organoids with cancer stem cell-like properties secrete exosomes and HSP90 in a 3D nanoenvironment

…, Y Namba, Y Murata, K Ohyama, M Shimomura… - PLoS …, 2018 - journals.plos.org
Ability to form cellular aggregations such as tumorspheres and spheroids have been used
as a morphological marker of malignant cancer cells and in particular cancer stem cells (CSC)…

[HTML][HTML] Programmed death-1 blockade enhances the antitumor effects of peptide vaccine-induced peptide-specific cytotoxic T lymphocytes

…, T Yoshikawa, M Shimomura… - International …, 2015 - spandidos-publications.com
Novel treatment modalities are required urgently in patients with hepatocellular carcinoma (HCC).
A vaccine that induces cytotoxic T lymphocytes (CTLs) is an ideal strategy for cancer, …

Phase I study of glypican-3-derived peptide vaccine therapy for patients with refractory pediatric solid tumors

…, K Shoda, K Nosaka, M Shimomura… - …, 2018 - Taylor & Francis
The carcinoembryonic antigen glypican-3 (GPC3) is a good target of anticancer immunotherapy
against pediatric solid tumors expressing GPC3. In this non-randomized, open-label, …

Peptide-based vaccines for hepatocellular carcinoma: a review of recent advances

J Charneau, T Suzuki, M Shimomura… - Journal of …, 2021 - Taylor & Francis
Primary liver cancer is the sixth most commonly diagnosed cancer and the third leading
cause of cancer-related deaths worldwide. After surgery, up to 70% of patients experience …

Genetically manipulated human embryonic stem cell-derived dendritic cells with immune regulatory function

…, S Hirata, D Fukuma, H Matsuyoshi, M Shimomura… - Stem …, 2007 - academic.oup.com
Genetically manipulated dendritic cells (DC) are considered to be a promising means for
antigen-specific immune therapy. This study reports the generation, characterization, and …

Ki67 expression and localization of T cells after neoadjuvant therapies as reliable predictive markers in rectal cancer

K Imaizumi, T Suzuki, M Kojima, M Shimomura… - Cancer …, 2020 - Wiley Online Library
Chemoradiotherapy (CRT) is the standard neoadjuvant therapy for locally advanced rectal
cancer (RC). However, neoadjuvant chemotherapy (NAC) also shows favorable outcomes. …

[HTML][HTML] Intratumoral peptide injection enhances tumor cell antigenicity recognized by cytotoxic T lymphocytes: a potential option for improvement in antigen-specific …

…, M Takahashi, T Iwama, K Horie, M Shimomura… - Cancer Immunology …, 2013 - Springer
Antigen-specific cancer immunotherapy is a promising strategy for improving cancer treatment.
Recently, many tumor-associated antigens and their epitopes recognized by cytotoxic T …

[HTML][HTML] First-in-human phase 1 study of IT1208, a defucosylated humanized anti-CD4 depleting antibody, in patients with advanced solid tumors

…, T Nakatsura, T Suzuki, M Shimomura… - … for immunotherapy of …, 2019 - Springer
Background Transient CD4 + T cell depletion led to the proliferation of tumor-specific CD8 +
T cells in the draining lymph node and increased infiltration of PD-1 + CD8 + T cells into the …

Circulating cancer‐associated extracellular vesicles as early detection and recurrence biomarkers for pancreatic cancer

Y Yoshioka, M Shimomura, K Saito, H Ishii… - Cancer …, 2022 - Wiley Online Library
Early detection of pancreatic ductal adenocarcinoma (PDAC) is essential for improving patient
survival rates, and noninvasive biomarkers are urgently required to identify patients who …