The enzyme aminopeptidase N (APN, also known as CD13) is a Zn 2+ dependent
membrane‐bound ectopeptidase that degrades preferentially proteins and peptides with a N‐terminal …

Neuroblastoma is a neural crest derived malignancy of the peripheral nervous system and
is the most common and deadliest tumor of infancy. It is characterized by clinical …

Aminopeptidases like aminopeptidase N (APN, also known as CD13) play an important role
not only in normal cellular functioning but also in the development of cancer, including …

The DNA repair enzyme O6-methylguanine-DNA methyltransferase (MGMT) is commonly
overexpressed in cancers and is implicated in the development of chemoresistance. The use …

… Malin Wickström and Cecilia Dyberg contributed equally to … Malin Wickström and Cecilia
Dyberg contributed equally to … Malin Wickström and Cecilia Dyberg contributed equally to this …

The thiocarbamate drug disulfiram has been used for decades in the treatment of alcohol
abuse. Disulfiram induces apoptosis in a number of tumor cell lines and was recently by us …

Cardiac glycosides have been reported to exhibit cytotoxic activity against several different
cancer types, but studies against colorectal cancer are lacking. In a screening procedure …

A series of dihalogenated chalcones and structurally related dienones were synthesized and
evaluated for their antiproliferative activity in 10 different cancer cell lines and for their effect …

Neuroblastoma is the most common extracranical tumor of childhood and the most deadly
tumor of infancy. It is characterized by early age onset and high frequencies of metastatic …

The cost of developing new drugs is a major obstacle for pharmaceutical companies and
academia with many drugs identified in the drug discovery process failing approval for clinical …