Naked DNA and adenoviral immunizations for immunotherapy of prostate cancer: a phase I/II clinical trial

M Mincheff, S Tchakarov, S Zoubak, D Loukinov… - European …, 2000 - karger.com
Introduction and Objectives: Animal studies have indicated that the use of syngeneic dendritic
cells that have been transfected ex vivo with DNA for tumor–specific antigen results in …

Blood transfusion and immunomodulation: a possible mechanism

M Mincheff, HT Meryman, V Kapoor, P Alsop, M Wötzel - Vox sanguinis, 1993 - karger.com
To induce an immunogenic response in vivo, an antigen-presenting (stimulator) cell must
present both antigen-specific (class II MHC) and an accessory signal to the CD4 T cell. Failure …

[HTML][HTML] Tularemia outbreak, Bulgaria, 1997–2005

…, B Popov, R Nenova, M Mincheff - Emerging Infectious …, 2006 - ncbi.nlm.nih.gov
The 1997–2005 tularemia outbreak in Bulgaria affected 285 people. Ten strains were isolated
from humans, a tick, a hare, and water. Amplified fragment length polymorphism typing of …

[HTML][HTML] Sertoli cells have a functional NALP3 inflammasome that can modulate autophagy and cytokine production

…, G Metodieva, S Toshkov, MV Metodiev, M Mincheff… - Scientific reports, 2016 - nature.com
… NOD1 detects the presence of L-Ala-γ-D-Glu-m-diaminopimelic acid (m-DAP), an amino
acid characteristic of most Gram-negative and some Gram-positive bacteria. NOD2 detects and …

In vivo transfection and/or cross-priming of dendritic cells following DNA and adenoviral immunizations for immunotherapy of cancer—changes in peripheral …

M Mincheff, I Altankova, S Zoubak, C Botev… - Critical reviews in …, 2001 - Elsevier
In order to provoke an immune response, a tumor vaccine should not only maximize antigen-specific
signals, but should also provide the necessary ‘co-stimulatory’ environment. One …

Blood transfusion, blood storage and immunomodulation

MS Mincheff, HT Meryman - Immunological Investigations, 1995 - Taylor & Francis
Allogeneic blood transfusion is the most frequent allotransplantation procedure performed on
a routine basis with no prior HLA-typing. Roughly 50% of the recipients of unprocessed red …

miR‐204 is dysregulated in metastatic prostate cancer in vitro

…, G Metodieva, D Zasheva, M Mincheff… - Molecular …, 2016 - Wiley Online Library
During cancer progression, the genome instability incurred rearrangement could possibly
turn some of the tumor suppressor micro‐RNAs into pro‐oncogenic ones. We aimed to …

Changes in donor leukocytes during blood storage. Implications on post‐transfusion immunomodulation and transfusion‐associated GVHD

M Mincheff - Vox sanguinis, 1998 - Wiley Online Library
Freshly drawn peripheral blood granulocytes, monocytes and NK cells express Fas‐L following
activation. Fully functional soluble Fas‐L (sFas‐L) is released and found in fresh plasma …

Humoral immune response in prostate cancer patients after immunization with gene-based vaccines that encode for a protein that is proteasomally degraded

…, I Altankova, S Zoubak, S Kyurkchiev, M Mincheff - Cancer Immunity, 2005 - AACR
… with citric acid buffer (0.1 M pH 3). In order to adjust the pH to neutral (pH 7), 100 µl 1 M
Tris buffer, pH 11, was added to each eluted IgG fraction. IgG fractions were tested by ELISA. …

[HTML][HTML] Micro-RNA-204 participates in TMPRSS2/ERG regulation and androgen receptor reprogramming in prostate cancer

…, MV Metodiev, G Metodieva, M Mincheff… - Hormones and …, 2017 - Springer
… two high-resolution scans (resolution of 30,000 at 400 m/z) followed by 20 MS/MS scans for
the … calibration was implemented by means of lock mass using the ambient ion of 445.12 m/z. …