Background It has been shown in many solid tumors that the overexpression of the pro-survival
Bcl-2 family members Bcl-xL and Mcl-1 confers resistance to a variety of …

Overly fibrotic wound healing can lead to excess scar formation, causing functional
impairment and undesirable cosmetic results. However, there are few successful treatments …

Background It has been shown in many solid tumors that the overexpression of the pro-survival
Bcl-2 family members Bcl-2/Bcl-xL and Mcl-1 confers resistance to a variety of …

Ineffective skin wound healing is a significant source of morbidity and mortality. Roughly 6.5
million Americans experience chronically open wounds and the cost of treating these …

BACKGROUND Excessive maternal immune system activation plays a central role in the
development of the hypertensive disorder of pregnancy preeclampsia (PE). The …

Introduction Traumatic brain injury (TBI), a significant cause of death and disability, causes,
as in any injury, an acute, innate immune response. A key component in the transition …

This study aimed to establish mechanistic links between the aging-associated changes in
the functional status of mast cells and the altered responses of mesenteric tissue and …

Background Lymphatic dysfunction has been linked to inflammation since the 1930s. Lymphatic
function in the gut and mesentery is grossly underexplored in models of inflammatory …

The maternal innate immune system plays an important role both in normal pregnancy as
well as hypertensive disorders of pregnancy including preeclampsia (PE). We propose four …

Purpose The aim of this study was to determine the relationship of birth weight and gestational
age with regulatory T cells (T regs ) in cord blood of human newborns. Methods Cord …